Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SB 204990是一种有效的、特异性 ATP 柠檬酸裂解酶抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 413 | 现货 | ||
5 mg | ¥ 917 | 现货 | ||
10 mg | ¥ 1,650 | 现货 | ||
25 mg | ¥ 3,550 | 现货 | ||
50 mg | ¥ 5,220 | 现货 | ||
100 mg | ¥ 7,380 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 995 | 现货 |
产品描述 | SB 204990 is an effective and specific ATP citrate lyase enzyme inhibitor. |
体外活性 | SB204990 treatment leads to a reduction in cytosolic Ac-CoA level and is thus expected to decrease acetylated and active β-catenin levels [1]. |
体内活性 | SB 204990 is absorbed into the systemic circulation when administered orally to rats. SB 204990 causes a dose-related decrease in plasma cholesterol (by up to 46%) and triglyceride levels (by up to 80%) in rats when administered in the diet (0.05-0.25%, w/w) for 1 week. SB 204990 (25 mg/kg per day) also decreases plasma cholesterol levels (by up to 23%) and triglyceride levels (by up to 38%) in the dog, preferentially decreasing low-density lipoprotein compared with high-density lipoprotein cholesterol levels [2]. |
分子量 | 389.27 |
分子式 | C18H22Cl2O5 |
CAS No. | 154566-12-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (256.89 mM)
H2O: 10 mg/mL (25.69 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 2.5689 mL | 12.8446 mL | 25.6891 mL | 64.2228 mL |
5 mM | 0.5138 mL | 2.5689 mL | 5.1378 mL | 12.8446 mL | |
10 mM | 0.2569 mL | 1.2845 mL | 2.5689 mL | 6.4223 mL | |
20 mM | 0.1284 mL | 0.6422 mL | 1.2845 mL | 3.2111 mL | |
DMSO | 50 mM | 0.0514 mL | 0.2569 mL | 0.5138 mL | 1.2845 mL |
100 mM | 0.0257 mL | 0.1284 mL | 0.2569 mL | 0.6422 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
SB 204990 154566-12-8 Metabolism ATP Citrate Lyase Inhibitor inhibit ACLY SB204990 SB-204990 inhibitor