Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-MTC is a selective inhibitor of type I nitric oxide synthase.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | ||
50 mg | ¥ 13,800 | 6-8周 | ||
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | S-MTC is a selective inhibitor of type I nitric oxide synthase. |
体外活性 | S-MTC (100?μM) is able to obviously reduce nitrite production (25.2±1.1?μM) as compared to Aβ1-42 treatment alone (38.3±2.7?μM) when administered after Aβ1-42 at the 1?h time point. S-MTC (10 or 100?μM) reduces cellular NO release in the absence of Aβ1-42. S-MTC (100?μM) reduces cell viability. Nitrite productions after Aβ1-42 and L-NOARG (100?μM) or Aβ1-42 and S-MTC (100?μM) treatments are significantly lower than Aβ1-42 alone (33.5±2.0 and 34.5±1.6?μM, respectively). S-MTC (100?μM) concentration decreases both MTT (87±1% of control) and NR (80±1% of control, respectively) levels [1]. |
体内活性 | S-MTC is a selective neuronal NOS-inhibitor. The HBO2-induced antinociception is significantly antagonized following pretreatment with S-MTC (i.c.v.). At a dose of 0.3 mg/kg, S-MTC (SMTC) induces a rise in mean blood pressure (BP). At doses of 1.0, 3.0, and 10 mg/kg, S-MTC causes a fall in heart rate, rises in BP, and vasoconstriction in all three vascular beds [2][3]. |
分子量 | 205.28 |
分子式 | C7H15N3O2S |
CAS No. | 156719-41-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
S-MTC 156719-41-4 Immunology/Inflammation NOS S MTC SMTC Inhibitor inhibitor inhibit