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Ropinirole hydrochloride

产品编号 T2592 CAS 91374-20-8

别名: SKF 101468 hydrochloride, SKF-101468A, Ropinirole HCl, 盐酸罗匹尼罗

Ropinirole hydrochloride (SKF-101468A) 是D3/D2受体激动剂，对 D2受体的Ki=29 nM。它对 hD2，hD3和 hD4受体的pEC50分别为 7.4、8.4 和 6.8。它对 D1受体没有亲和力。它对帕金森氏病具有潜在的研究价值。

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Ropinirole hydrochloride Chemical Structure

Ropinirole hydrochloride, CAS 91374-20-8

规格	价格/CNY	货期
10 mg	￥ 198	现货
25 mg	￥ 327	现货
50 mg	￥ 547	现货
100 mg	￥ 970	现货
200 mg	￥ 1,620	现货
500 mg	￥ 2,730	现货
1 mL * 10 mM (in DMSO)	￥ 271	现货

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其他形式的 Ropinirole hydrochloride:

Ropinirole
询价

选择批次

纯度: 99.95%

纯度: 99.87%

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生物活性

化学信息

存储 & 溶解度

参考文献

相关产品

产品描述	Ropinirole hydrochloride (SKF-101468A) is a selective dopamine D2 receptors agonist (Ki: 29 nM). Ropinirole hydrochloride (SKF-101468A) is the hydrochloride salt form of ropinirole, a non-ergot dopamine agonist with antiparkinsonian property.
靶点活性	D2 receptor:29 nM(Ki)
体外活性	Ropinirole scavenges free radicals and suppresses lipid peroxidation in the Fe2+–Water2 reaction system. [2]
体内活性	Ropinirole (50 mg/kg, i.p.) causes biphasic spontaneous locomotor activity in mice. Ropinirole (0.05-1.0 mg/kg SC) dose-dependently inhibits the dyskinesias induced by 2-di-n-propylamino-5,6-di-hydroxytetralin in mice. Ropirtirole, at doses of 1 and 10 μg, injected unilaterally directly into the striatum of the rat causes marked, contralateral (away from the side of injection) asymmetry and circling in mice. Ropinirole (0.05-1.0 mg/kg SC or 0.1 mg/kg PO) reverses all motor and behavioural deficits induced by MPTP in marmosets. [1] Ropinirole (2 mg/kg, i.p.) for 7 days increases GSH, catalase and SOD activities in the striatum and protected striatal dopaminergic neurons against 6-hydroxydopamine (6-OHDA) in mice. [2] Ropinirole (0.2 mg/kg, i.p.) improves the use of previously akinetic forelimb and produced robust circling behavior in lesioned rats with striatal over-expression of both D2R and D3R compared to lesioned animals that received blank vector. The subtherapeutic dose of ropinirole generates only modest motor effects in lesioned rats with sole over-expression of D2R or D3R. [3] Ropinirole (1-8 mg t.i.d.) is rapidly and completely absorbed with oral bioavailability of 55%, clearance of 780 mL/min, elimination half-life of 6 hours in healthy volunteer. Since the major route of elimination for Ropinirole is by the CYP enzyme system, mainly by CYP1A2 and also by CYP3A4, inhibition of the former and possibly the latter may reduce the agent's clearance and lead to drug accumulation. [4] Ropinirole (0.25 mg-4.0 mg per day) treatment significantly improves patients' ability to initiate sleep, the amount of stage 2 sleep and sleep adequacy compared with placebo. Periodic limb movements with arousal per hour decreases from 7.0 to 2.5 with ropinirole but increases from 4.2 to 6.0 with placebo. Periodic limb movements while awake per hour decreases from 56.5 to 23.6 with ropinirole but increases from 46.6 to 56.1 with placebo. [5]
激酶实验	PARP1 enzyme activity is measured by using a commercial assay kit with the exception that cell lysates containing wild-type PARP1 or PARP Y907 mutant are used in place of the PARP1 protein included with the kit. Total lysate (500 ng) is added to each reaction. The dose course of PARP inhibitor Veliparib (ABT-888) is from 0.01 to 1,000 μM. PARP enzyme activity of wild-type and mutants is determined after incubation with the substrate is measured using a plate reader[2].

别名	SKF 101468 hydrochloride, SKF-101468A, Ropinirole HCl, 盐酸罗匹尼罗
分子量	296.84
分子式	C16H24N2O·HCl
CAS No.	91374-20-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 14.8 mg/mL (50 mM)

H2O: 29.7 mg/mL (100 mM)

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
DMSO / H2O	1 mM	3.3688 mL	16.8441 mL	33.6882 mL	84.2205 mL
	5 mM	0.6738 mL	3.3688 mL	6.7376 mL	16.8441 mL
	10 mM	0.3369 mL	1.6844 mL	3.3688 mL	8.422 mL
	20 mM	0.1684 mL	0.8422 mL	1.6844 mL	4.211 mL
	50 mM	0.0674 mL	0.3369 mL	0.6738 mL	1.6844 mL
H2O	100 mM	0.0337 mL	0.1684 mL	0.3369 mL	0.8422 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

质量

浓度

容积

分子量

浓度 (起始)

容积 (起始)

浓度 (终)

容积 (终)

溶液体积

质量

配液浓度

参考文献

1. Eden RJ, et al. Pharmacol Biochem Behav, 1991, 38(1), 147-154. 2. Iida M, et al. Brain Res, 1999, 838(1-2), 51-59. 3. Matsukawa N, et al. Brain Res, 2007, 1160, 113-123. 4. Lam YW, et al. Pharmacotherapy, 2000, 20(1 Pt 2), 17S-25S. 5. Allen R, et al. Sleep, 2004, 27(5), 907-914.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

% DMSO+

% +

% Tween 80+

% ddH₂O

%DMSO+

计算重置

计算结果如下:

工作液浓度: mg/ml;

母液配置方法: mg 药物溶于 μL DMSO (母液浓度为 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

备注:

要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到，包括如何准备库存溶液，如何存储产品，以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Ropinirole hydrochloride 91374-20-8 GPCR/G Protein Neuroscience Dopamine Receptor Parkinson's disease SKF-101468 inhibit Inhibitor Ropinirole Hydrochloride SKF 101468 SKF 101468 hydrochloride SKF-101468A Ropinirole HCl SKF 101468 Hydrochloride SKF101468 Hydrochloride Ropinirole SKF101468 盐酸罗匹尼罗 SKF-101468 Hydrochloride inhibitor

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Ropinirole hydrochloride

存储

溶解度

溶液配制表

计算器

输入分子式，点击计算，可计算出产品的分子量。

参考文献

相关产品

相关化合物库

剂量换算

体内实验配液计算器

技术支持

Keywords