Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rodatristat ethyl (KAR5585) 是一种首新型具有口服活性和有效性的 tryptophan hydroxylase 1 (TPH1) 抑制剂,低浓度下可显著降低 5-hydroxytryptamine (5-HT) 的水平并降低肺动脉高压 (PAH),
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 15,000 | 10-14周 | ||
50 mg | ¥ 19,800 | 10-14周 | ||
100 mg | ¥ 27,900 | 10-14周 |
产品描述 | Rodatristat ethyl (KAR5585) is a first-of-its-kind orally active and potent tryptophan hydroxylase 1 (TPH1) inhibitor that significantly reduces 5-hydroxytryptamine (5-HT) levels and decreases pulmonary arterial hypertension (PAH) at low concentrations. |
体内活性 | In male Sprague-Dawley rats, oral administration of rodatristat ethyl at doses of 100 or 200 mg/kg once daily for 28 days results in a dose-dependent decrease in serum, gut, and lung 5-HT levels. This treatment significantly reduces pulmonary arterial pressure as well as pulmonary vessel wall thickness and occlusion in rats with monocrotaline (MCT)-induced pulmonary hypertension[2]. |
别名 | RVT-014, KAR5585, RVT-1201 |
分子量 | 590.04 |
分子式 | C29H31ClF3N5O3 |
CAS No. | 1673571-51-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (152.53 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.6948 mL | 8.474 mL | 16.948 mL | 42.37 mL |
5 mM | 0.339 mL | 1.6948 mL | 3.3896 mL | 8.474 mL | |
10 mM | 0.1695 mL | 0.8474 mL | 1.6948 mL | 4.237 mL | |
20 mM | 0.0847 mL | 0.4237 mL | 0.8474 mL | 2.1185 mL | |
50 mM | 0.0339 mL | 0.1695 mL | 0.339 mL | 0.8474 mL | |
100 mM | 0.0169 mL | 0.0847 mL | 0.1695 mL | 0.4237 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rodatristat ethyl 1673571-51-1 GPCR/G Protein Metabolism Neuroscience Hydroxylase 5-HT Receptor RVT-014 KAR-5585 KAR 5585 KAR5585 RVT-1201 Inhibitor inhibitor inhibit