Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ro 90-7501 是一种淀粉样 β42 (Aβ42) 原纤维和 TPR 依赖性 PP5 抑制剂,是一种新型宫颈癌细胞放射增敏剂,可抑制 ATM 磷酸化 ,促进细胞凋亡,诱导细胞周期停滞。Ro 90-7501 具有抗病毒活性和潜在的抗癌活性,抑制 ATM 磷酸化和 DNA 修复,抑制HCMV。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 689 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,730 | 现货 | ||
50 mg | ¥ 4,630 | 现货 | ||
100 mg | ¥ 7,880 | 现货 | ||
500 mg | ¥ 15,700 | 现货 |
产品描述 | Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV. |
体外活性 |
Compared to control HeLa and ME-180 cells, Ro 90-7501 significantly enhances radiation sensitivity. Following irradiation, Ro 90-7501 markedly increases apoptosis and impairs the cell cycle. Post-irradiation, Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2[2]. RO 90-7501 itself does not affect IFN-β and NFκB promoter activity but significantly enhances poly I:C-induced IFN-β promoter activation and dose-dependently inhibits NF-κB activation. Treatment with RO 90-7501 significantly enhances the antiviral activity of poly I:C[1]. |
体内活性 | Treatment with Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; continuous for 21 days; female BALB/c nude mice) significantly delays tumor growth and markedly reduces tumor volume[2]. |
别名 | RO-90-7501 |
分子量 | 340.38 |
分子式 | C20H16N6 |
CAS No. | 293762-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (88.14 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9379 mL | 14.6895 mL | 29.3789 mL | 73.4473 mL |
5 mM | 0.5876 mL | 2.9379 mL | 5.8758 mL | 14.6895 mL | |
10 mM | 0.2938 mL | 1.4689 mL | 2.9379 mL | 7.3447 mL | |
20 mM | 0.1469 mL | 0.7345 mL | 1.4689 mL | 3.6724 mL | |
50 mM | 0.0588 mL | 0.2938 mL | 0.5876 mL | 1.4689 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ro 90-7501 293762-45-5 Apoptosis DNA Damage/DNA Repair Metabolism Neuroscience PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Phosphatase ATM/ATR Gamma-secretase RO-90-7501 Ro 907501 Ro 90 7501 Inhibitor inhibitor inhibit