Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rimiducid 是一种可渗透脂质的他克莫司类似物,是一种二聚剂,通过交联 FKBP 结构域起作用。它将 Caspase 9 自杀开关二聚化并迅速诱导细胞凋亡。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 568 | 现货 | ||
2 mg | ¥ 837 | 现货 | ||
5 mg | ¥ 1,690 | 现货 | ||
10 mg | ¥ 2,860 | 现货 | ||
25 mg | ¥ 4,750 | 现货 | ||
50 mg | ¥ 6,780 | 现货 | ||
100 mg | ¥ 9,190 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,680 | 现货 |
产品描述 | Rimiducid is a lipid-permeable tacrolimus analogue, homodimerizing an analogue of human protein fkbp12 and binding to wild-type fkbp12 with 1000-fold lower affinity. Rimiducid is a dimerizer agent that acts by cross-linking the FKBP domains. It dimerizes the Caspase 9 suicide switch and rapidly induces apoptosis. |
靶点活性 | FKBP:(EC50)0.1 nM |
体外活性 | AP1903, a bivalent 'dimerizer' drug that binds FKBP and induces Fas cross-linking.?A single 2-hour treatment eliminated approximately 80% of T cells, and multiple exposures induced further apoptosis.?T cells were eliminated regardless of their proliferation state, suggesting that the AP1903/Fas system, which contains only human components, is a promising alternative to HSV-tk for treating GVHD[2]. |
体内活性 | Constitutive hGH secretion provides a convenient and accurate way to monitor the number of viable cells in vivo because hGH has a serum half-life of only ≈3 min in mice. Over 3 consecutive days, we implanted these cells i.m. into nude mice, and treated the animals i.v. with various doses of Rimiducid, and then determined serum hGH levels as a measure of the number of surviving cells. Rimiducid (AP1903; i.v.,0.01, 0.1, 1, 10, and 100 mg/kg) elicits a dose-dependent decrease in serum human GH levels, with a half-maximal effective dose of 0.4±0.1 mg/kg[1]. |
分子量 | 1411.63 |
分子式 | C78H98N4O20 |
CAS No. | 195514-63-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (35.42 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 0.7084 mL | 3.542 mL | 7.084 mL | 17.71 mL |
5 mM | 0.1417 mL | 0.7084 mL | 1.4168 mL | 3.542 mL | |
10 mM | 0.0708 mL | 0.3542 mL | 0.7084 mL | 1.771 mL | |
20 mM | 0.0354 mL | 0.1771 mL | 0.3542 mL | 0.8855 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Rimiducid 195514-63-7 Apoptosis Metabolism Others Fatty Acid Synthase AP1903 Inhibitor FKBP AP-1903 AP 1903 inhibit FK506-binding protein inhibitor