Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 763 | 5日内发货 | ||
25 mg | ¥ 5,780 | 6-8周 | ||
50 mg | ¥ 7,510 | 6-8周 | ||
100 mg | ¥ 13,500 | 6-8周 |
产品描述 | Ribocil-C is a highly selective bacterial riboflavin riboswitches inhibitor. |
体外活性 | Ribocil-C is a small-molecule synthetic mimic of FMN that binds the FMN riboswitch of multiple GN bacteria, including Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, to inhibit ribB expression, RF synthesis, and consequently arrest bacterial growth. Ribocil-C specifically inhibits dual FMN riboswitches, separately controlling RF biosynthesis and uptake processes essential for Staphylococcus aureus growth and pathogenesis. Ribocil-C controls expression of de novo riboflavin biosynthesis in Escherichia coli [1][2]. |
体内活性 | Ribocil-C treatment groups (60 and 120 mg kg21 ribocil-C) show a dose-dependent reduction in the bacterial burden of 1.87 and 3.29 log10[CFU per g spleen] reduction respectively versus shamtreated mice. There is no mortality or gross effects of toxicity observed [2]. |
分子量 | 419.5 |
分子式 | C21H21N7OS |
CAS No. | 1825355-56-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 24.6 mg/mL (58.64 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.3838 mL | 11.919 mL | 23.8379 mL | 59.5948 mL |
5 mM | 0.4768 mL | 2.3838 mL | 4.7676 mL | 11.919 mL | |
10 mM | 0.2384 mL | 1.1919 mL | 2.3838 mL | 5.9595 mL | |
20 mM | 0.1192 mL | 0.5959 mL | 1.1919 mL | 2.9797 mL | |
50 mM | 0.0477 mL | 0.2384 mL | 0.4768 mL | 1.1919 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ribocil-C 1825355-56-3 Microbiology/Virology Antibacterial RibocilC Ribocil C Inhibitor inhibitor inhibit