Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1 complex.
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 458 | 5日内发货 | ||
5 mg | ¥ 822 | 5日内发货 | ||
10 mg | ¥ 1,190 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 852 | 5日内发货 |
Ribociclib hydrochloride 的其他形式现货产品:
产品描述 | Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1 complex. |
靶点活性 | CDK4:10 nM, CDK6:39 nM |
体外活性 | Ribociclib hydrochloride treatment of two neuroblastoma cell lines (BE2C and IMR5) with demonstrated sensitivity to CDK4/6 inhibition results in a dose-dependent accumulation of cells in the G0/G1 phase of the cell cycle. This G0/G1 arrest becomes significant at Ribociclib concentrations of 100 nM (p=0.007) and 250 nM (p=0.01), respectively. Treatment with Ribociclib obviously inhibits substrate adherent growth relative to the control in 12 of the 17 neuroblastoma cell lines examined (mean IC50=306±68 nM, considering sensitive lines only, where sensitivity is defined as an IC50 of less than 1 μM. Treating a panel of 17 neuroblastoma cell lines with Ribociclib across a four-log dose range (10 to 10,000 nM) [2]. |
体内活性 | Tumor growth is significantly delayed throughout the 21 days of treatment in mice harboring the BE2C or 1643 xenografts (both, p<0.0001), although growth resumed post-treatment. CB17 immunodeficient mice bearing BE2C, NB-1643 (MYCN amplified, sensitive in vitro), or EBC1 (non-amplified, resistant in vitro) xenografts are treated once daily for 21 days with Ribociclib (200 mg/kg) or with vehicle control. This dosing strategy is well tolerated, as no weight loss or other signs of toxicity are observed in any of the xenograft models [2]. |
别名 | LEE011 hydrochloride, 瑞博西尼盐酸盐 |
分子量 | 471 |
分子式 | C23H31ClN8O |
CAS No. | 1211443-80-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mg/mL (21.23 mM), Sonication is recommended.
DMSO: 7.69 mg/mL (16.33 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O / DMSO | 1 mM | 2.1231 mL | 10.6157 mL | 21.2314 mL | 53.0786 mL |
5 mM | 0.4246 mL | 2.1231 mL | 4.2463 mL | 10.6157 mL | |
10 mM | 0.2123 mL | 1.0616 mL | 2.1231 mL | 5.3079 mL | |
H2O | 20 mM | 0.1062 mL | 0.5308 mL | 1.0616 mL | 2.6539 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Ribociclib hydrochloride 1211443-80-9 Cell Cycle/Checkpoint CDK LEE-011 Hydrochloride LEE011 hydrochloride 瑞博西尼盐酸盐 LEE011 Hydrochloride Ribociclib Hydrochloride LEE 011 Hydrochloride Inhibitor inhibitor inhibit