Resveratrol

产品编号: T1558 别名:

白藜芦醇,SRT 501,trans-Resveratrol

Resveratrol是一种多酚类植物抗毒素，具有抗氧化和化学预防活性。它具有广泛的目标，包括 COX、SIRT、LOC 等。

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CAS：501-36-0

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生物活性化学信息储存和溶解度信息参考文献引用文献

产品描述

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum of targets including COX, SIRT, LOC, etc.

体外活性

Resveratrol inhibits cellular events associated with tumor initiation, promotion, and progression. Resveratrol inhibited the hydroperoxidase activity of COX-1 (ED50 = 3.7 μM) [1]. Resveratrol inhibits the activity of COX-1 and COX-2 (IC50s: 1.1 μM and 1.3 μM for COX-1 and COX-2, respectively) [2]. Resveratrol inhibited TPA-induced DNA binding of NF-kB. Moreover, resveratrol reduced the levels of p65/RelA, a functionally active subunit of NF-kB in nuclear fractions prepared from TPA-treated mouse skin. Resveratrol pretreatment significantly inhibited the phosphorylation of p65-(Ser-536) induced by TPA. Resveratrol pretreatment significantly attenuated TPA-induced stimulation of IKKa and IKKb activity [3]. DNA polymerase inhibiting activity of resveratrol was found to occur at 10 μM in an SV40 viral DNA replication assay. Resveratrol inhibits DNA polymerases α and δ (IC50s: 3.3 and 5 μM, respectively) [4].

体内活性

Resveratrol (RSV) treatment significantly upregulated eNOS gene expression and the levels of phosphorylated CREB in the aorta compared with the untreated control mice. Simultaneously, RSV treatment was observed to upregulate PKA activity and cGMP levels and inhibited superoxide generation in the aorta compared with untreated mice. Compared to vehicle-treated mice, chronic RSV treatment resulted in a significant improvement in endothelium-dependent vasorelaxation response to Ach. Treatment with RSV markedly attenuated the area of atherosclerotic lesions [5].

细胞实验

HAECs were treated with RSV in the presence of isobutylmethylxanthine (IBMX). The reaction was stopped by adding ice-cold 6% trichloroacetic acid and the supernatant fractions of the cellular lysates were extracted, dried and acetylated. Cyclic GMP levels were determined by an enzyme immunoassay kit and results standardized by protein levels [5].

动物实验

Eight-week male apoE-/- mice (C57BL/6 background) were used in the study. Mice were housed in photobiologic light-exposure chambers with a 12:12-h light:dark cycle, and eat food ad libitum. Mice were randomly divided into two groups: one group receiving a high cholesterol diet (HCD, 21% fat, 19.5% casein, and 1.5% cholesterol), the other receiving HCD supplemented with RSV (200 mg/100 g diet). All mice were fed for 8 weeks. To identify the potential role of PKA, some mice were treated with PKA specific inhibitor (KT5720, 1.2 mg/kg) via intraperitoneal injection once a day at the last 4 weeks. The animal experiments were conducted according to the institutional guidelines of Guangdong Provincial People's Hospital [5].

Cas No.

501-36-0

分子式

C14H12O3

分子量

228.247

别名

白藜芦醇;SRT 501;trans-Resveratrol;Resveratrol

参考文献

[1]Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT[J]. Oncology Reports. 2021, 45(4): 1-1.[2]Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway[J]. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.[3]Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system[J]. Chemistry & Biodiversity. 2021 [4]Zhang K, Pan X, Zheng J, et al. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation[J]. Molecular Biology Reports. 2020, 47(3): 2149-2159.[5]Calamini B, et al. Pleiotropic mechanisms facilitated by resveratrol and its metabolites. Biochem J. 2010 Jul 15;429(2):273-82.[6]Kundu JK, et al. Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis. 2006 Jul;27(7):1465-74.[7]Li J, et al. Resveratrol improves endothelial dysfunction and attenuates atherogenesis in apolipoprotein E-deficient mice. J Nutr Biochem. 2019 Feb 10;67:63-71.[8]Pirola L, et al. Resveratrol: one molecule, many targets. IUBMB Life. 2008 May;60(5):323-32.[9]Pang K, Li B, Tang Z, et al. Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis[J]. Molecular medicine reports. 2020, 22(4): 3440-3452.[10]Jang M, et al. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science. 1997 Jan 10;275(5297):218-20.

引用文献

[1]Wang B, He B S, Ruan X L, et al. An integrated microfluidics platform with high-throughput single-cell cloning array and concentration gradient generator for efficient cancer drug effect screening. Military Medical Research. 2022, 9(1): 1-17.[2]Lu J, Lu Z, Liu L, et al. Identification of crocin as a new hIAPP amyloid inhibitor via a simple yet highly biospecific screening system. Chemistry & Biodiversity. 2021 [3]Qin Z, Fang X, Sun W, et al. Deactylation by SIRT1 enables liquid–liquid phase separation of IRF3/IRF7 in innate antiviral immunity. Nature Immunology. 2022: 1-15 [4]Geng W, Guo X, Zhang L, et al. Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway Resveratrol inhibits proliferation, migration and invasion of multiple myeloma cells via NEAT1-mediated Wnt/β-catenin signaling pathway. Biomedicine & Pharmacotherapy. 2018 Nov;107:484-494.[5]Su M, Zhao W, Li Y, et al. Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis. Nutrients. 2022, 14(21): 4518.[6]Fernandes J C, Schemitt E G, Da Silva J, et al. Combination of Trans-Resveratrol and ε-Viniferin Induces a Hepatoprotective Effect in Rats with Severe Acute Liver Failure via Reduction of Oxidative Stress and MMP-9 Expression. Nutrients. 2021, 13(11): 3677.[7]Zareifi D S, Chaliotis O, Chala N, et al. A network-based computational and experimental framework for repurposing compounds toward the treatment of non-alcoholic fatty liver disease. Iscience. 2022, 25(3): 103890 [8]Zhou H, Ning Y, Zeng G, et al. Curcumin promotes cell cycle arrest and apoptosis of acute myeloid leukemia cells by inactivating AKT. Oncology Reports. 2021, 45(4): 1-1.[9]Zhang K, Pan X, Zheng J, et al. SIRT1 protects against aortic dissection by regulating AP-1/decorin signaling-mediated PDCD4 activation. Molecular Biology Reports. 2020, 47(3): 2149-2159 [10]Pang K, Li B, Tang Z, et al. Resveratrol inhibits hypertrophic scars formation by activating autophagy via the miR-4654/Rheb axis. Molecular medicine reports. 2020, 22(4): 3440-3452.

储存和溶解度

DMSO:42 mg/mL (184 mM)
H2O:<1 mg/mL
Ethanol:<1 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years

剂量换算 Resveratrol 501-36-0

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体内配方的制备方法：取 μL DMSO 主液，加入 μL PEG300，混匀澄清，再加 μL Tween 80，混匀澄清，再加 μL ddH₂O, 混匀澄清。

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要按顺序从左向右依次添加助溶剂。可配合物理方法，如涡流、超声波或热水浴使之帮助溶解。

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Keywords

Sirtuin SRT-501 Autophagy Bacterial Apoptosis Fungal Antibiotic Inhibitor inhibit Resveratrol Mitochondrial Autophagy 白藜芦醇 IKK I kappa B kinase Mitophagy SRT501 Keap1-Nrf2 IκB kinase SRT 501 trans-Resveratrol 501-36-0

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Resveratrol

白藜芦醇,SRT 501,trans-Resveratrol

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