Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Resorcinolnaphthalein 是一种特异性的血管紧张素转换酶 2 激活剂,EC50=19.5 μM。Resorcinolnaphthalein 能够用于高血压和肾纤维化的研究
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 145 | 现货 | ||
5 mg | ¥ 295 | 现货 | ||
10 mg | ¥ 496 | 现货 | ||
25 mg | ¥ 795 | 现货 | ||
50 mg | ¥ 1,180 | 现货 | ||
100 mg | ¥ 1,990 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 379 | 现货 |
产品描述 | Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM). |
靶点活性 | ACE2:(EC50)19.5 μM |
体外活性 | ACE2 activity in a dose-dependent manner enhanced by Resorcinolnaphthalein (100 μM) and XNT (EC50 values of 19.5 μM and 20.1 μM, respectively).ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology. |
体内活性 | resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner. Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10 mg/kg, spontaneously hypertensive rats decreased 71+/-9 mm Hg and Wistar-Kyoto rats decreased 21+/-8 mm Hg; P<0.05). Chronic infusion of the xanthenone (120 microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17 mm Hg; 2-way ANOVA; P<0.05), whereas it had no effect in Wistar-Kyoto rats. Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats[1]. |
分子量 | 382.36 |
分子式 | C24H14O5 |
CAS No. | 41307-63-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (313.84 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.6153 mL | 13.0767 mL | 26.1534 mL | 65.3834 mL |
5 mM | 0.5231 mL | 2.6153 mL | 5.2307 mL | 13.0767 mL | |
10 mM | 0.2615 mL | 1.3077 mL | 2.6153 mL | 6.5383 mL | |
20 mM | 0.1308 mL | 0.6538 mL | 1.3077 mL | 3.2692 mL | |
50 mM | 0.0523 mL | 0.2615 mL | 0.5231 mL | 1.3077 mL | |
100 mM | 0.0262 mL | 0.1308 mL | 0.2615 mL | 0.6538 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Resorcinolnaphthalein 41307-63-5 Endocrinology/Hormones RAAS fibrosis ACE2 hypertension renal perivascular reversal inhibit myocardial Inhibitor Angiotensin-converting Enzyme (ACE) inhibitor