Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ROCK2-IN-2 是 ROCK2 的特异性抑制剂(IC50 <1 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 873 | 现货 | ||
5 mg | ¥ 2,530 | 现货 | ||
10 mg | ¥ 3,990 | 现货 | ||
25 mg | ¥ 6,390 | 现货 | ||
50 mg | ¥ 8,730 | 现货 | ||
100 mg | ¥ 11,700 | 现货 | ||
500 mg | ¥ 23,600 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 2,780 | 现货 |
产品描述 | ROCK2-IN-2 is a selective inhibitor of ROCK2 (IC50 of <1 μM). |
靶点活性 | ROCK2:1 μM |
体外活性 | Rho-associated protein kinase (ROCK) is a member of the serine-threonine protein kinase family including two isoforms, ROCK1 and ROCK2. ROCK2-IN-2 is involved in a number of cellular functions, which include, for example, actin organization, cell adhesion, cell migration, and cytokinesis. ROCK2-IN-2 can be used for research on the treatment of multiple medical disorders, such as fibrosis, inflammatory disorders, autoimmune disorders, and cardiovascular disorders[1]. |
分子量 | 360.39 |
分子式 | C18H12N6OS |
CAS No. | 1995065-79-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 95 mg/mL (263.60 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7748 mL | 13.8739 mL | 27.7477 mL | 69.3693 mL |
5 mM | 0.555 mL | 2.7748 mL | 5.5495 mL | 13.8739 mL | |
10 mM | 0.2775 mL | 1.3874 mL | 2.7748 mL | 6.9369 mL | |
20 mM | 0.1387 mL | 0.6937 mL | 1.3874 mL | 3.4685 mL | |
50 mM | 0.0555 mL | 0.2775 mL | 0.555 mL | 1.3874 mL | |
100 mM | 0.0277 mL | 0.1387 mL | 0.2775 mL | 0.6937 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ROCK2-IN-2 1995065-79-6 Cell Cycle/Checkpoint Cytoskeletal Signaling Stem Cells ROCK inhibit ROCK2 IN 2 ROCK2IN2 ROK Rho-kinase ROCK-2-IN-2 Inhibitor Rho-associated kinase Rho-associated protein kinase inhibitor