Powder: -20°C for 3 years | In solvent: -80°C for 1 year
RO2959 Hydrochloride (RO2959 HCl) 是选择性CRAC 通道抑制剂,IC50为 402 nM。它是人IL-2产生的有效抑制剂,有效阻断 T 细胞受体触发的基因表达和 T 细胞功能途径。它是由Orai1/Stim1通道介导的钙存储进入的有效阻滞剂,IC50为 25 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 996 | 现货 | ||
5 mg | ¥ 2,860 | 现货 | ||
10 mg | ¥ 4,220 | 现货 | ||
25 mg | ¥ 6,590 | 现货 | ||
50 mg | ¥ 8,890 | 现货 | ||
100 mg | ¥ 11,900 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,150 | 现货 |
产品描述 | RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
靶点活性 | CRAC channel:402 nM |
体外活性 | RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction). |
别名 | RO2959 HCl |
分子量 | 463.93 |
分子式 | C21H20ClF2N5OS |
CAS No. | 1219927-22-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (21.55 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1555 mL | 10.7775 mL | 21.555 mL | 53.8874 mL |
5 mM | 0.4311 mL | 2.1555 mL | 4.311 mL | 10.7775 mL | |
10 mM | 0.2155 mL | 1.0777 mL | 2.1555 mL | 5.3887 mL | |
20 mM | 0.1078 mL | 0.5389 mL | 1.0777 mL | 2.6944 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
RO2959 Hydrochloride 1219927-22-6 Immunology/Inflammation Membrane transporter/Ion channel Metabolism IL Receptor Calcium Channel Interleukin RO-2959 Hydrochloride IP3 SOCE RO 2959 Hydrochloride Ca2+ release-activated Ca2+ channels Interleukin Related inhibit IL-2 Stim1 CRAC Channel anti-proliferation RO 2959 Calcium release-activated channels T-cell RO-2959 Orai1 heart RO2959 Inhibitor failure RO2959 HCl inhibitor