Powder: -20°C for 3 years | In solvent: -80°C for 1 year
R162 是谷氨酸脱氢酶 (GDH1/GLUD1) 抑制剂,具有抗癌的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 297 | 现货 | ||
5 mg | ¥ 728 | 现货 | ||
10 mg | ¥ 1,130 | 现货 | ||
25 mg | ¥ 2,180 | 现货 | ||
50 mg | ¥ 3,290 | 现货 | ||
100 mg | ¥ 4,720 | 现货 | ||
500 mg | ¥ 9,780 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 697 | 现货 |
产品描述 | R162 is an effective glutamate dehydrogenase 1 (GDH1) inhibitor. |
体外活性 | R162 decreased intracellular fumarate levels attenuated GPx activity by inhibited GDH1 activity, increased ROS levels, and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 inhibits tumor growth potential and cell proliferation of human cancer cells. |
体内活性 | In xenograft tumor mouse models, R162 (30 mg/kg/day, i.p.) does not cause a significant histopathological change between the vehicle-treated and R162-treated groups, nor alters complete blood counts, or hematopoietic properties. Compared with control mice, R162 (20 mg/kg/day) markedly decreases tumor growth and masses and effectively inhibits GDH1 activity in resected tumors from xenograft nude mice. |
分子量 | 264.28 |
分子式 | C17H12O3 |
CAS No. | 64302-87-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
R162 64302-87-0 Metabolism Dehydrogenase inhibit Inhibitor R 162 R-162 inhibitor