首页 GPCR/G Protein 5-HT Receptor Quetiapin
Quetiapin
编号 T0162     别名: ICI204636, Quetiapine
CAS 111974-69-7     分子式 C21H25N3O2S     分子量 383.51
靶点: 5-HT; Adrenergic Receptor; Dopamine; H1 receptor; mAChR;
Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.
选择批次  
纯度 99.5%
规格 库存 单价 数量
10 mg 待询 489.00
50 mg 待询 907.00
100 mg 待询 1107.00
200 mg 待询 1660.00
1 mL * 10 mM (in DMSO) 待询 349.00
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生物活性

产品描述

Quetiapine is used for the therapy of schizophrenia, and for the treatment of acute manic episodes associated with bipolar I disorder. The mechanism of quetiapine' action is thought by mediated through antagonist activity at serotonin and dopamine receptors. Specifically, the D1 and D2 dopamine, the α1 adrenoreceptor and α2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also can inhibit the histamine H1 receptor.

靶点活性

5-HT,

Adrenergic Receptor,

Dopamine,

H1 receptor,

mAChR,

体外活性

体内活性

化学信息

分子量

383.51

分子式

C21H25N3O2S

CAS

111974-69-7

溶解度

DMSO: 36 mg/mL

Water: <1 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.607 ml 13.037 ml 26.075 ml
5 mM 0.521 ml 2.607 ml 5.215 ml
10 mM 0.261 ml 1.304 ml 2.607 ml
50 mM 0.052 ml 0.261 ml 0.521 ml
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