Powder: -20°C for 3 years | In solvent: -80°C for 1 year
QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 10,600 | 8-10周 | ||
50 mg | ¥ 13,800 | 8-10周 | ||
100 mg | ¥ 17,500 | 8-10周 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,190 | 8-10周 |
产品描述 | QC6352 is a selective and effective KDM4C inhibitor (IC50: 35 nM). |
靶点活性 | KDM4C:35 nM |
体外活性 | QC6352 is an effective KDM4C inhibitor (IC50: 35±8 nM). QC6352 blocks the proliferation and self-renewal of BCSCs. In a concentration-dependent manner QC6352 dramatically decreases the anchorage-independent sphere-forming capacity of BCSC1 and BCSC2. The protein levels of (Epidermal growth factor receptor) EGFR are reduced in both BCSC1 and BCSC2 upon treatment with QC6352 [1][2]. |
体内活性 | QC6352 strongly affects tumor growth and the final tumor weight of both BCSC1 and BCSC2 xenografts. QC6352 treatment is well tolerated and does not affect body weight of the mice. Treatment with the KDM4 inhibitor QC6352 blocks BCSC xenograft tumor growth[2]. |
分子量 | 387.47 |
分子式 | C24H25N3O2 |
CAS No. | 1851373-36-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (64.52 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5808 mL | 12.9042 mL | 25.8084 mL | 64.5211 mL |
5 mM | 0.5162 mL | 2.5808 mL | 5.1617 mL | 12.9042 mL | |
10 mM | 0.2581 mL | 1.2904 mL | 2.5808 mL | 6.4521 mL | |
20 mM | 0.129 mL | 0.6452 mL | 1.2904 mL | 3.2261 mL | |
50 mM | 0.0516 mL | 0.2581 mL | 0.5162 mL | 1.2904 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
QC6352 1851373-36-8 Chromatin/Epigenetic Histone Demethylase QC 6352 QC-6352 Inhibitor inhibitor inhibit