Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Protirelin (Thyroliberin) 是高度保守的神经肽,具有促甲状腺激素水平的激素控制作用,及神经调节功能。 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Protirelin Acetate(24305-27-9 free base) 的水溶性和稳定性通常比游离态更好。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 218 | 5日内发货 | ||
5 mg | ¥ 497 | 5日内发货 | ||
10 mg | ¥ 749 | 5日内发货 | ||
25 mg | ¥ 1,260 | 5日内发货 | ||
50 mg | ¥ 1,870 | 5日内发货 | ||
1 mL * 10 mM (in DMSO) | ¥ 563 | 5日内发货 |
产品描述 | Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin. |
靶点活性 | Thyroid hormone receptor: |
体内活性 | Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes. Protirelin may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin. |
动物实验 | Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted. |
别名 | Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, 普罗瑞林, TRF |
分子量 | 362.38 |
分子式 | C16H22N6O4 |
CAS No. | 24305-27-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 67 mg/mL (184.9 mM)
DMSO: 67 mg/mL (184.9 mM)
H2O: 66 mg/mL (182.1 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO / H2O | 1 mM | 2.7595 mL | 13.7977 mL | 27.5953 mL | 68.9884 mL |
5 mM | 0.5519 mL | 2.7595 mL | 5.5191 mL | 13.7977 mL | |
10 mM | 0.276 mL | 1.3798 mL | 2.7595 mL | 6.8988 mL | |
20 mM | 0.138 mL | 0.6899 mL | 1.3798 mL | 3.4494 mL | |
50 mM | 0.0552 mL | 0.276 mL | 0.5519 mL | 1.3798 mL | |
100 mM | 0.0276 mL | 0.138 mL | 0.276 mL | 0.6899 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Protirelin 24305-27-9 Endocrinology/Hormones Metabolism Endogenous Metabolite Thyroid hormone receptor(THR) THR Lopremone pGlu-His-Pro-NH2 Synthetic thyrotropin-releasing hormone Inhibitor Thyroliberin Thyroid Hormone Receptor TRH 普罗瑞林 inhibit TRF inhibitor