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Protirelin

Protirelin

产品编号 T6956   CAS 24305-27-9
别名: Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, 普罗瑞林, TRF

Protirelin (Thyroliberin) 是高度保守的神经肽,具有促甲状腺激素水平的激素控制作用,及神经调节功能。 在相同实验条件下,摩尔浓度相同的化合物盐形式与游离态具有相同的生物活性,但盐形式 Protirelin Acetate(24305-27-9 free base) 的水溶性和稳定性通常比游离态更好。

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Protirelin Chemical Structure
Protirelin, CAS 24305-27-9
规格 价格/CNY 货期 数量
1 mg ¥ 218 5日内发货
5 mg ¥ 497 5日内发货
10 mg ¥ 749 5日内发货
25 mg ¥ 1,260 5日内发货
50 mg ¥ 1,870 5日内发货
1 mL * 10 mM (in DMSO) ¥ 563 5日内发货
产品目录号及名称: Protirelin (T6956)
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Protirelin (Thyroliberin) is a tripeptide that stimulates the release of thyrotropin and prolactin.
靶点活性 Thyroid hormone receptor:
体内活性 Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes. Protirelin may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin.
动物实验 Protirelin (TRH tartRatse) is dissolved in physiological saline (Rats).RatsNinety male Wistar rats weighing 200-250 g are subjected to the study. In the first experiment, 50 rats are divided into five groups randomly. Four doses of Protirelin dissolved in physiological saline, i. e., 1 mg/kg, 5 mg/kg, 10 mg/kg and 20 mg/kg, are administered intraperitoneally to the four groups and saline to the remaining control group. Rectal temperature is measured at the place 5 cm inner from the anus with the electronic thermister before and after treatment with Protirelin or saline. In the second experiment, 40 rats are thyroidectomized or sham-operated under the anesthesia by thiopental sodium. Ten days after the operation, 20 mg/kg of Protirelin or saline is administered to the thyroidectomized and sham-operated animals by i. p. and rectal temperature is measured using the same method as used in the first experiment. These two experiments are undertaken from 1 p, m, to 4 p. m. and the room temperature is kept at 24±1°C through the experiments including the breeding period. For a statistical analysis, Student's t test (two-tailed) is adopted.
别名 Lopremone, pGlu-His-Pro-NH2, Synthetic thyrotropin-releasing hormone, Thyroliberin, TRH, 普罗瑞林, TRF
分子量 362.38
分子式 C16H22N6O4
CAS No. 24305-27-9

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 67 mg/mL (184.9 mM)

DMSO: 67 mg/mL (184.9 mM)

H2O: 66 mg/mL (182.1 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / H2O 1 mM 2.7595 mL 13.7977 mL 27.5953 mL 68.9884 mL
5 mM 0.5519 mL 2.7595 mL 5.5191 mL 13.7977 mL
10 mM 0.276 mL 1.3798 mL 2.7595 mL 6.8988 mL
20 mM 0.138 mL 0.6899 mL 1.3798 mL 3.4494 mL
50 mM 0.0552 mL 0.276 mL 0.5519 mL 1.3798 mL
100 mM 0.0276 mL 0.138 mL 0.276 mL 0.6899 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Van Sinay E,etal.Evolutionarily conserved TRH neuropeptide pathway regulates growth in Caenorhabditis elegans.Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4065-E4074. 2. Noda Y,etal.Hyperthermia induced by thyrotropin-releasing hormone (TRH, protirelin) in the rat.Kurume Med J. 1979;26(2):107-12.
(D-Trp12,Tyr34)-pTH (7-34) amide (bovine) acetate L-Thyroxine sodium Methimazole Glutaurine aceate Resmetirom Carbimazole 2,2-BIS(2-HYDROXY-5-BIPHENYLYL)PROPANE REVERSE T3

相关化合物库

该产品包含在如下化合物库中:
Ro5类药天然产物库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Protirelin 24305-27-9 Endocrinology/Hormones Metabolism Endogenous Metabolite Thyroid hormone receptor(THR) THR Lopremone pGlu-His-Pro-NH2 Synthetic thyrotropin-releasing hormone Inhibitor Thyroliberin Thyroid Hormone Receptor TRH 普罗瑞林 inhibit TRF inhibitor

 

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