Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Procyanidin A1 (Proanthocyanidin A1) 是一种原花青素二聚体,具有抗过敏作用,可抑制蛋白激酶 C 激活下游脱粒或 RBL-213 细胞内部储存的 Ca2+流入。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 828 | 现货 | ||
5 mg | ¥ 2,490 | 现货 | ||
10 mg | ¥ 3,730 | 现货 | ||
25 mg | ¥ 5,960 | 现货 | ||
50 mg | ¥ 7,880 | 现货 | ||
100 mg | ¥ 10,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 4,120 | 现货 |
产品描述 | Procyanidin A1 (Proanthocyanidin A1) has antiallergic effects, it inhibits degranulation downstream of protein kinase C activation or Ca2+; influx from an internal store in RBL-2H3 cells. |
体外活性 | We found that a peanut-skin extract (PSE) inhibits the degranulation induced by antigen stimulation of rat basophilic leukemia (RBL-2H3) cells. A low-molecular-weight fraction from PSE, PSEL, also had inhibitory activity against allergic degranulation. A main polyphenol in PSEL was purified by gel chromatography and fractionated by YMC-gel ODS-AQ 120S50 column. Electrospray ionization mass spectrometry (ESI-MS) analysis of the purified polyphenol gave m/z 599 [M+Na]?. Based on the results of 1H-NMR, 13C-NMR spectra, and optical rotation analysis, the polyphenol was identified as Procyanidin A1. It inhibited the degranulation caused by antigen stimulation at the IC50 of 20.3 μM. Phorbol-12-myristate-13-acetate (PMA) and 2,5,-di(tert-butyl)-1,4-hydroquinone (DTBHQ)-induced processes of degranulation were also inhibited by Procyanidin A1[1] |
别名 | 原花青素 A1, Proanthocyanidin A1, 原花色素A1 |
分子量 | 576.5 |
分子式 | C30H24O12 |
CAS No. | 103883-03-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (95.4 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7346 mL | 8.673 mL | 17.3461 mL | 43.3651 mL |
5 mM | 0.3469 mL | 1.7346 mL | 3.4692 mL | 8.673 mL | |
10 mM | 0.1735 mL | 0.8673 mL | 1.7346 mL | 4.3365 mL | |
20 mM | 0.0867 mL | 0.4337 mL | 0.8673 mL | 2.1683 mL | |
50 mM | 0.0347 mL | 0.1735 mL | 0.3469 mL | 0.8673 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Procyanidin A1 103883-03-0 Chromatin/Epigenetic Cytoskeletal Signaling Membrane transporter/Ion channel Metabolism LDL Calcium Channel PKC Inhibitor Proanthocyanidin A 1 Procyanidin A 1 Protein kinase C inhibit 原花青素 A1 Proanthocyanidin A1 Proanthocyanidin A-1 原花色素A1 Procyanidin A-1 inhibitor