Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pivanex (Pivalyloxymethyl butyrate) 是丁酸的一种衍生物,是具有口服活性的 HDAC 抑制剂。Pivanex 通过下调 bcr-abl 蛋白增强凋亡。Pivanex 显示出抗转移和抗血管生成的活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 327 | 现货 | ||
10 mg | ¥ 497 | 现货 | ||
25 mg | ¥ 980 | 现货 | ||
50 mg | ¥ 1,490 | 现货 | ||
100 mg | ¥ 2,320 | 现货 | ||
200 mg | ¥ 3,460 | 现货 | ||
500 mg | ¥ 5,530 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 363 | 现货 |
产品描述 | Pivanex (Pivalyloxymethyl butyrate) is an orally active HDAC inhibitor and an antimetastatic and antiangiogenic agent. Pivanex downregulates the Bcr-Abl protein and enhances apoptosis. |
体外活性 | Pivanex has selective toxicity to acute leukemia and drug-resistant primary leukemia and cancer cell lines. Pivanex (200 μM) causes enhancement in the G2-M phase, moderate enhancement in the S phase, and a slight reduction in G0-G1 of the cell cycle. Pivanex (100-500 μM) shows significant anti-proliferation activity in K562 cells. Pivanex (100-500 μM) also increases apoptosis and caspase activity in K562 cells [1][2]. |
体内活性 | Pivanex treatment also marked delays in the end stage of disease as defined by the onset of body mass loss. Pivanex (200 mg/kg, b.i.d, daily) obviously improves the survival of SMN7 SMA mice [3]. |
别名 | Pivalyloxymethyl butyrate, AN-9 |
分子量 | 202.25 |
分子式 | C10H18O4 |
CAS No. | 122110-53-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (494.44 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.9444 mL | 24.7219 mL | 49.4438 mL | 123.6094 mL |
5 mM | 0.9889 mL | 4.9444 mL | 9.8888 mL | 24.7219 mL | |
10 mM | 0.4944 mL | 2.4722 mL | 4.9444 mL | 12.3609 mL | |
20 mM | 0.2472 mL | 1.2361 mL | 2.4722 mL | 6.1805 mL | |
50 mM | 0.0989 mL | 0.4944 mL | 0.9889 mL | 2.4722 mL | |
100 mM | 0.0494 mL | 0.2472 mL | 0.4944 mL | 1.2361 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pivanex 122110-53-6 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair Tyrosine Kinase/Adaptors Bcr-Abl HDAC Chronic leukemia muscular Acute ALL atrophy Inhibitor lung Pivalyloxymethyl butyrate Histone deacetylases NSCLC myelogenous lymphoblastic AN9 cancer CML AN 9 spinal K562 inhibit AN-9 Pivalyloxymethyl Butyrate inhibitor