Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pitolisant hydrochloride (Ciproxidine) 是一种有效的、选择性的组胺 H3 受体反向激动剂,Ki 为0.16 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,230 | 现货 | ||
50 mg | ¥ 1,950 | 现货 | ||
100 mg | ¥ 3,320 | 现货 | ||
200 mg | ¥ 4,750 | 现货 | ||
500 mg | ¥ 7,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | Pitolisant hydrochloride (Ciproxidine) is a potent and selective inverse agonist of the histamine H3 receptor(Ki : 0.16 nM). |
靶点活性 | H3 receptor:0.16 nM(ki) |
体内活性 | Mice fed with high-fat diet showed more weight gain throughout the 12-week period of inducing obesity. Animals fed with high-fat diet and treated with pitolisant (next 14 days) showed significantly less weight gain than mice from the control group consuming a high-fat diet. From the 10th day of the pitolisant administration, a statistically significant difference in body weight between the groups was observed. Metformin, which served as a positive control, reduced body weight from the ninth day of administration onward[1]. |
动物实验 | Male CD-1 mice were fed on high-fat diet consisting of 40% fat blend (Labofeed B with 40% lard) for 14 weeks, water and 30% sucrose available ad libitum. Control mice were fed on a standard diet and drank water only. After 12 weeks, mice with obesity induced via their diet were randomly divided into three equal groups that had the same mean body weight and were treated intraperitoneally with test compounds at the following doses: pitolisant 10 mg/kg bw/day or metformin 100 mg/kg bw/day; control group: vehicle =1% Tween 80, 0.35 ml/kg (high-fat/sugar diet + vehicle = obesity control group) once daily in the morning, between 9:00 and 10:00 AM for 14 days. Control mice (control without obesity) were maintained on a standard diet, with intraperitoneal administration of vehicle = 1% Tween 80, 0.35 ml/kg (standard diet + vehicle = control group). Water and sucrose were measured daily, immediately prior to administration of drugs. Animals always had free access to feed, water and sucrose[1]. |
别名 | 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐, BF 2649, Ciproxidine |
分子量 | 332.31 |
分子式 | C17H27Cl2NO |
CAS No. | 903576-44-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43 mg/mL (129.40 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.0092 mL | 15.0462 mL | 30.0924 mL | 75.231 mL |
5 mM | 0.6018 mL | 3.0092 mL | 6.0185 mL | 15.0462 mL | |
10 mM | 0.3009 mL | 1.5046 mL | 3.0092 mL | 7.5231 mL | |
20 mM | 0.1505 mL | 0.7523 mL | 1.5046 mL | 3.7615 mL | |
50 mM | 0.0602 mL | 0.3009 mL | 0.6018 mL | 1.5046 mL | |
100 mM | 0.0301 mL | 0.1505 mL | 0.3009 mL | 0.7523 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pitolisant hydrochloride 903576-44-3 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor 1-[3-[3-(4-氯丙基)丙氧基]丙基]-哌啶盐酸盐 BF2649 inhibit Pitolisant Hydrochloride Inhibitor BF 2649 Ciproxidine Pitolisant BF-2649 inhibitor