Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pinostrobin 是一种 PCSK9抑制剂,可抑制 PCSK9 的催化活性。它是能够在多种植物中发现的黄酮类化合物,并具有抗氧化,抗炎,抗癌和神经保护作用。它是有前景的胆固醇调节和脂质管理剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 728 | 现货 | ||
5 mg | ¥ 1,820 | 现货 | ||
10 mg | ¥ 2,930 | 现货 | ||
25 mg | ¥ 4,770 | 现货 | ||
50 mg | ¥ 6,630 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,630 | 现货 |
产品描述 | Pinostrobin, a potent flavonoid inducer, exerts a neuroprotective effect against Aα2(25-35)-induced neurotoxicity in PC12 cells, at least in part, via inhibiting oxidative damage and calcium overload, as well as suppressing the mitochondrial pathway of cellular apoptosis. |
体外活性 | Pinostrobin was isolated from the dichloromethane extract of Renealmia alpinia leaves. The protective properties of the extract and of Pinostrobin against the indirect hemolytic, coagulant and proteolytic effects of Bothrops asper venom were evaluated in vitro, and the anti-hemorrhagic and anti-inflammatory activity were evaluated in vivo. Renealmia alpinia extract significantly inhibited the proteolytic activity and indirect hemolytic activity of Bothrops asper venom at a venom:extract ratio of 1:20. Moreover, the present data demonstrate that Pinostrobin may mitigate some venom-induced local tissue damage due to hemorrhagic effects, and the compound is also responsible for the analgesic and anti-inflammatory activity of the extract from Renealmia alpinia. This is the first report to describe Pinostrobin in the species Renealmia alpinia and its properties in vitro against Bothrops asper venom[1] |
分子量 | 270.28 |
分子式 | C16H14O4 |
CAS No. | 480-37-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 60 mg/ml (221.98 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.6999 mL | 18.4993 mL | 36.9987 mL | 92.4967 mL |
5 mM | 0.74 mL | 3.6999 mL | 7.3997 mL | 18.4993 mL | |
10 mM | 0.37 mL | 1.8499 mL | 3.6999 mL | 9.2497 mL | |
20 mM | 0.185 mL | 0.925 mL | 1.8499 mL | 4.6248 mL | |
50 mM | 0.074 mL | 0.37 mL | 0.74 mL | 1.8499 mL | |
100 mM | 0.037 mL | 0.185 mL | 0.37 mL | 0.925 mL |
中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
大叶紫珠 | Callicarpa macrophμllaVahl | 平 | 辛, 苦 | 肝, 肺, 胃 |
中成药名称 | 处方组成 | 主治疾病 | 中成药类型 |
紫地宁血散 | 大叶紫珠,地菍 | 口服。一次8克,一日3-4次。 | 止血药 |
紫地宁血颗粒 | 大叶紫珠,地菍 | 口服。一次1包,一日3-4次。 | 止血药 |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pinostrobin 480-37-5 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation Metabolism Neuroscience Beta Amyloid IL Receptor Serine/threonin kinase TNF Threonine proteases inhibit Serine proteases Inhibitor foxO3a cholesterol anti-cancer,neuroprotective Ser/Thr Protease Serine endopeptidases anti-inflammatory PCSK9 anti-oxidant inhibitor