Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Picolinamide (Picolinoylamide) 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 198 | 现货 | ||
50 mg | ¥ 356 | 现货 | ||
100 mg | ¥ 553 | 现货 | ||
500 mg | ¥ 1,854 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 160 | 现货 |
产品描述 | Picolinamide (Picolinoylamide) is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells. |
靶点活性 | PARP:95 μM |
体外活性 | In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1] |
体内活性 | Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3]. |
别名 | 2-Pyridinecarboxamide, 2-Carbamoylpyridine, 2-吡啶甲酰胺, 2-Picolinamide, Picolinoylamide |
分子量 | 122.12 |
分子式 | C6H6N2O |
CAS No. | 1452-77-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 23 mg/mL (188.3 mM)
DMSO: 23 mg/mL (188.3 mM)
H2O: 22 mg/mL (180.2 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO / H2O | 1 mM | 8.1887 mL | 40.9433 mL | 81.8867 mL | 204.7167 mL |
5 mM | 1.6377 mL | 8.1887 mL | 16.3773 mL | 40.9433 mL | |
10 mM | 0.8189 mL | 4.0943 mL | 8.1887 mL | 20.4717 mL | |
20 mM | 0.4094 mL | 2.0472 mL | 4.0943 mL | 10.2358 mL | |
50 mM | 0.1638 mL | 0.8189 mL | 1.6377 mL | 4.0943 mL | |
100 mM | 0.0819 mL | 0.4094 mL | 0.8189 mL | 2.0472 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Picolinamide 1452-77-3 Chromatin/Epigenetic DNA Damage/DNA Repair PARP 2-Pyridinecarboxamide 2-Carbamoylpyridine 2-吡啶甲酰胺 2-Picolinamide Picolinoylamide Inhibitor inhibitor inhibit