store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Philanthotoxin 74 dihydrochloride 是一种 AMPAR 拮抗剂,对 GluR3 和 GluR1 的 IC50 分别为 263 和 296 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 413 | 现货 | ||
5 mg | ¥ 899 | 现货 | ||
50 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 999 | 现货 |
产品描述 | Philanthotoxin 74 dihydrochloride is an antagonist of AMPAR with IC50s of 263 and 296 nM for GluR3 and GluR1. |
靶点活性 | GluR1:296 nM |
体外活性 | Philanthotoxin 74 dihydrochloride inhibits the two major subtypes of GluA2R-containing AMPARs, GluA1/A2R and GluA2R/A3 in the micromolar concentration range, when these are coexpressed with γ-2 in oocytes. Philanthotoxin 74 dihydrochloride (500 μM) fully inhibits GluA1/A2R receptors and produces 10% inhibition at GluA2R/A3 receptors. Philanthotoxin 74 dihydrochloride (100 and 500 μM) displays a pronounced channel block (> 80%) of GluA1/A2R but minimal block (less than 10%) of GluA2R/A3. Philanthotoxin 74 dihydrochloride inhibits these receptors nonselectively, with IC50 values of about 30 μM, in both the presence and absence of γ-2[1]. |
别名 | PhTx-74 HCl, PhTx 74 dihydrochloride |
分子量 | 507.54 |
分子式 | C24H44Cl2N4O3 |
CAS No. | 1227301-51-0 |
store at low temperture,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (177.33 mM), sonification is recommended.
H2O: 40 mg/mL (78.81 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.9703 mL | 9.8514 mL | 19.7029 mL | 49.2572 mL |
5 mM | 0.3941 mL | 1.9703 mL | 3.9406 mL | 9.8514 mL | |
10 mM | 0.197 mL | 0.9851 mL | 1.9703 mL | 4.9257 mL | |
20 mM | 0.0985 mL | 0.4926 mL | 0.9851 mL | 2.4629 mL | |
50 mM | 0.0394 mL | 0.197 mL | 0.3941 mL | 0.9851 mL | |
DMSO | 100 mM | 0.0197 mL | 0.0985 mL | 0.197 mL | 0.4926 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Philanthotoxin 74 dihydrochloride 1227301-51-0 Membrane transporter/Ion channel Neuroscience iGluR GluR PhTx 74 Philanthotoxin 74 Dihydrochloride Philanthotoxin 74 PhTx-74 HCl PhTx 74 dihydrochloride PhTx 74 Dihydrochloride Inhibitor inhibitor inhibit