Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Phenoxodiol (Idronoxil) 是合成genestein 的类似物,激活线粒体caspase 系统,抑制XIAP,使癌细胞对fas 介导的凋亡敏感。它在细胞周期的G1/S 期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1。它通过稳定可分裂复合物抑制DNA 拓扑异构酶II,从而阻止DNA 复制。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 678 | 现货 | ||
2 mg | ¥ 992 | 现货 | ||
5 mg | ¥ 1,630 | 现货 | ||
10 mg | ¥ 2,650 | 现货 | ||
25 mg | ¥ 4,470 | 现货 | ||
50 mg | 特惠询价 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,790 | 现货 |
产品描述 | Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II. |
体外活性 | Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation[3]. |
体内活性 | Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model[3]. |
别名 | 脱氢雌马酚, Dehydroequol, Idronoxil, Haginin E |
分子量 | 240.25 |
分子式 | C15H12O3 |
CAS No. | 81267-65-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (208.12 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.1623 mL | 20.8117 mL | 41.6233 mL | 104.0583 mL |
5 mM | 0.8325 mL | 4.1623 mL | 8.3247 mL | 20.8117 mL | |
10 mM | 0.4162 mL | 2.0812 mL | 4.1623 mL | 10.4058 mL | |
20 mM | 0.2081 mL | 1.0406 mL | 2.0812 mL | 5.2029 mL | |
50 mM | 0.0832 mL | 0.4162 mL | 0.8325 mL | 2.0812 mL | |
100 mM | 0.0416 mL | 0.2081 mL | 0.4162 mL | 1.0406 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Phenoxodiol 81267-65-4 Apoptosis DNA Damage/DNA Repair Proteases/Proteasome Caspase IAP Topoisomerase p53 inhibit 脱氢雌马酚 Inhibitor XIAP CP70 Dehydroequol Idronoxil Haginin E ovarian cancer prostate cancer inhibitor