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Paricalcitol

产品编号 TQ0200 CAS 131918-61-1

Paricalcitol 是一种 vitamin D receptor 激活剂，是一种 vitamin D 类似物，用于研究继发性甲状旁腺功能亢进，该疾病与慢性肾功能衰竭有关。

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Paricalcitol, CAS 131918-61-1

规格	价格/CNY	货期
1 mg	￥ 1,370	现货
5 mg	￥ 3,450	现货
10 mg	￥ 4,910	现货
25 mg	￥ 7,850	现货
50 mg	￥ 10,500	现货
100 mg	￥ 14,270	现货

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其他形式的 Paricalcitol:

Paricalcitol-D6
询价

选择批次

纯度: 99.5%

纯度: 98.59%

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生物活性

化学信息

存储 & 溶解度

参考文献

产品描述	Paricalcitol is a vitamin D receptor agonist. It is used for the prevention and treatment of secondary hyperparathyroidism associated with chronic renal failure.
体外活性	Paricalcitol (30 nM; HP + PC) produces a significant reduction in calcification relative to the observed in cells in HP medium. Paricalcitol causes a reduction in the levels of nuclear β-catenin to a level similar to that observed in control cells [1].
体内活性	Paricalcitol (300 ng/kg/day) significantly decreases Tau and prevents LV dysfunction in mice. It reduces mRNA expression of ANP, fibronectin and collagen III in the TAC-pari mice [2].
动物实验	After TAC or sham surgery, a subset of the mice is treated with paricalcitol which activates the VDR, at a final dose of 300 ng/kg/day. Paricalcitol is dissolved in a 95% propylene glycol and 5% ethyl alcohol solution. Mice were intraperitoneally injected with paricalcitol (or vehicle only) three times per week on Monday, Wednesday, and Friday for five consecutive weeks. An established anti-hypertrophic and anti-fibrotic treatment, namely the angiotensin II receptor blocker (ARB) losartan is also included. Previous experiments have shown it is feasible and efficacious to dissolve losartan in the drinking water at a concentration of 30 mg/kg/day; mice are treated for five consecutive weeks. So, in total eight groups are studied. Sham (n=10), TAC (n=10), Sham + losartan (Sham-los, n=10), TAC + losartan (TAC-los, n=10), Sham + paricalcitol (Sham-pari, n=10), TAC + paricalcitol (TAC-pari, n=10), Sham + paricalcitol + losartan (Sham-combi, n=10) and TAC + paricalcitol + losartan (TAC-combi, n=10) [2].

分子量	416.64
分子式	C27H44O3
CAS No.	131918-61-1

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

H2O: Insoluble

Ethanol: 12 mg/mL (38.8 mM), Sonication is recommended.

DMSO: 95 mg/mL (228.02 mM), Sonication is recommended.

溶液配制表

可选溶剂	浓度体积质量	1 mg	5 mg	10 mg	25 mg
Ethanol / DMSO	1 mM	2.4002 mL	12.0008 mL	24.0015 mL	60.0038 mL
	5 mM	0.48 mL	2.4002 mL	4.8003 mL	12.0008 mL
	10 mM	0.24 mL	1.2001 mL	2.4002 mL	6.0004 mL
	20 mM	0.12 mL	0.6 mL	1.2001 mL	3.0002 mL
DMSO	50 mM	0.048 mL	0.24 mL	0.48 mL	1.2001 mL
DMSO	100 mM	0.024 mL	0.12 mL	0.24 mL	0.6 mL

计算器

摩尔浓度计算器

稀释计算器

配液计算器

分子量计算器

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浓度

容积

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容积 (起始)

浓度 (终)

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参考文献

1. Martinez-Moreno JM, et al. In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/beta-catenin activation. Am J Physiol Renal Physiol. 2012 Aug 8. 2. Meems LM, et al. The vitamin D receptor activator paricalcitol prevents fibrosis and diastolic dysfunction in a murine model of pressure overload. J Steroid Biochem Mol Biol. 2012 Jul 16;132(3-5):282-289.

剂量换算

对于不同动物的给药剂量换算，您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10 只，您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL)，如您需要配置的浓度超过该产品的溶解度，请先与我们联系。

体内配方的制备方法：取 50 μL DMSO 主液，加入 300 μL PEG300，混匀澄清，再加 50 μL Tween 80，混匀澄清，再加 600 μL ddH2O, 混匀澄清。

第一步：请输入动物实验的基本信息

剂量

mg/kg

每只动物体重

给药体积

μL

动物数量

第二步：请输入动物体内配方组成，不同的产品配方组成不同，如有配方需求，可先联系我们提供正确的体内配方。

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