Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Parecoxib (SC 69124) 是一种有效的选择性 COX-2 抑制剂,是 Valdecoxib 的前药。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 109 | 现货 | ||
5 mg | ¥ 218 | 现货 | ||
10 mg | ¥ 297 | 现货 | ||
25 mg | ¥ 496 | 现货 | ||
50 mg | ¥ 745 | 现货 | ||
100 mg | ¥ 1,230 | 现货 | ||
200 mg | ¥ 1,830 | 现货 | ||
500 mg | ¥ 3,120 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 511 | 现货 |
产品描述 | Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor. |
体内活性 | Parecoxib, a selected cyclooxygenase-2 inhibitor, ameliorates neurologic deficits in the behavior studies and brain damage, including neuronal death, and brain edema in the MCP-1 and NeuN immunostaining in rats subjected to SAH(Subarachnoid Hemorrhage). Parecoxib is able to reduce early COX2 expression via inhibiting cJNK (p55) expression (dose-dependently), reduce IL-1β, IL-6 and MCP-1( at 2000 ug/kg/day at the time point of 24hr and 72hr after the induction of SAH), IL-8 (of the dosage of 2000 ug/kg/day at 24hr after the induction of SAH), and also reduce cleaved caspase-1 (at 1000 and 2000 ug/kg/day) and Caspase-9a (at 2000 ug/kg/day). Parecoxib reduces the NMDAR-1, and NMDAR-2a (at 1000 and 2000 ug/kg) after the induction of SAH[2]. |
别名 | SC 69124, 帕瑞昔布, Vorth-P, Valus-P |
分子量 | 370.42 |
分子式 | C19H18N2O4S |
CAS No. | 198470-84-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 2 mg/mL (5.4 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 69 mg/mL (186.3 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / DMSO | 1 mM | 2.6996 mL | 13.4982 mL | 26.9964 mL | 67.491 mL |
5 mM | 0.5399 mL | 2.6996 mL | 5.3993 mL | 13.4982 mL | |
DMSO | 10 mM | 0.27 mL | 1.3498 mL | 2.6996 mL | 6.7491 mL |
20 mM | 0.135 mL | 0.6749 mL | 1.3498 mL | 3.3745 mL | |
50 mM | 0.054 mL | 0.27 mL | 0.5399 mL | 1.3498 mL | |
100 mM | 0.027 mL | 0.135 mL | 0.27 mL | 0.6749 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Parecoxib 198470-84-7 Immunology/Inflammation Neuroscience COX osteoarthritis POCD rheumatoid arthritis pain Cyclooxygenase cognitive dysfunction postoperative SC 69124 SC-69124 coxibs analgesia SC69124 Inhibitor inhibit 帕瑞昔布 Vorth-P chronic inflammatory condition Valus-P inhibitor