Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pantoprazole sodium (Pantecta) 是一种具有口服活性的质子泵抑制剂,是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,IC50为 6.8 μM。它可以改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。它联合阿霉素可显著增加肿瘤生长延迟。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 148 | 现货 | ||
50 mg | ¥ 198 | 现货 | ||
100 mg | ¥ 289 | 现货 | ||
500 mg | ¥ 928 | 现货 | ||
1 g | ¥ 1,370 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 160 | 现货 |
产品描述 | Pantoprazole sodium (Pantecta) is the sodium salt form of a substituted benzimidazole with proton pump inhibitor activity. Pantoprazole sodium is a lipophilic, weak base that crosses the parietal cell membrane and enters the acidic parietal cell canaliculus where it becomes protonated, producing the active metabolite sulfenamide, which forms an irreversible covalent bond with two sites of the H+/K+-ATPase enzyme located on the gastric parietal cell, thereby inhibiting both basal and stimulated gastric acid production. |
体外活性 | pantoprazole (PPZ) inhibits tumor cells proliferation, inducs apoptosis and decreases the expression of HIF-1α protein[2]. Pantoprazole affects the intracellular distribution of HIF-1α in SGC-7901 cells, which might be one of the mechanisms of its chemosensitizing effect on cancer cells[3]. |
体内活性 | After PPZ treatment, apoptotic cell death is seen selectively in cancer cells and is accompanied with extracellular signal-regulated kinase deactivation. By contrast, normal gastric mucosal cells show the resistance to PPZ-induced apoptosis through the overexpression of antiapoptotic regulators including HSP70 and HSP27. In a xenograft model of nude mice, administration of PPZ significantly inhibits tumorigenesis and induces large-scale apoptosis of tumor cells[4]. |
细胞实验 | Pantoprazole sodium salts are resuspended in normal saline (0.85%) at 5 mg/ml immediately prior to use. When the SGC-7901 cells have reached 60–70% confluence, PPZ is added at a final concentration of 20 µg/ml, and the cells are cultured for additional experiments. For example, The SGC-7901 cells are seeded in 100 µl of medium per well, at a density of 1×104/well, in 96-well plates and treated with PPZ for 24 h. (Only for Reference) |
别名 | Pantecta, 泮托拉唑钠盐, SKF96022 sodium, SKF96022 (sodium), BY1023 (sodium), 泮托拉唑钠, BY-1023 sodium, Pantoloc |
分子量 | 405.35 |
分子式 | C16H14F2N3NaO4S |
CAS No. | 138786-67-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 75 mg/mL (185 mM)
H2O: 74 mg/mL (182.6 mM)
Ethanol: 75 mg/mL (185 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O / Ethanol | 1 mM | 2.467 mL | 12.335 mL | 24.67 mL | 61.6751 mL |
5 mM | 0.4934 mL | 2.467 mL | 4.934 mL | 12.335 mL | |
10 mM | 0.2467 mL | 1.2335 mL | 2.467 mL | 6.1675 mL | |
20 mM | 0.1234 mL | 0.6168 mL | 1.2335 mL | 3.0838 mL | |
50 mM | 0.0493 mL | 0.2467 mL | 0.4934 mL | 1.2335 mL | |
100 mM | 0.0247 mL | 0.1234 mL | 0.2467 mL | 0.6168 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pantoprazole sodium 138786-67-1 Angiogenesis Apoptosis Autophagy Chromatin/Epigenetic Membrane transporter/Ion channel Others Proton pump HIF stability Pantecta 泮托拉唑钠盐 inhibit anti-secretory SKF-96022 BY-1023 SKF96022 sodium H+/K+-ATPase BY1023 SKF96022 (sodium) exosome BY1023 (sodium) PPI orally BY 1023 MCF-7 Pantoprazole Proton Pump Doxorubicin Inhibitor 泮托拉唑钠 SKF 96022 anti-ulcer SKF96022 BY-1023 sodium release A431 Pantoloc inhibitor