Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pantoprazole (BY1023) 是一种质子泵抑制剂,用于短期治疗由胃食管反流病引起的食管糜烂和溃疡。它联合阿霉素可显著增加肿瘤生长延迟。它是一种取代的苯并咪唑,是H+/K+-ATPase 抑制剂,可改善 pH 值稳定性,具有抗分泌和抗溃疡的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 233 | 现货 | ||
100 mg | ¥ 328 | 现货 | ||
200 mg | ¥ 529 | 现货 | ||
500 mg | ¥ 1,160 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 129 | 现货 |
产品描述 | Pantoprazole (BY1023) is a proton pump inhibitor used for short-term treatment of erosion and ulceration of the esophagus caused by gastroesophageal reflux disease. |
体外活性 | PPZ(Pantoprazole) inhibits the proliferation of tumor cells, induces apoptosis and downregulates the expression of PKM2, which contributes to the current understanding of the functional association between PPZ and PKM2(The human M2 isoform of pyruvate kinase)[2]. Ex vivo studies showed that pantoprazole inhibited TOPK activities in JB6 Cl41 cells and HCT 116 colorectal cancer cells. Moreover, knockdown of TOPK in HCT 116 cells decreased their sensitivities to pantoprazole. |
别名 | SKF96022, 泮托拉唑, BY1023 |
分子量 | 383.37 |
分子式 | C16H15F2N3O4S |
CAS No. | 102625-70-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 71 mg/mL (185.2 mM)
Ethanol: 71 mg/mL (185.2 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 2.6084 mL | 13.0422 mL | 26.0845 mL | 65.2112 mL |
5 mM | 0.5217 mL | 2.6084 mL | 5.2169 mL | 13.0422 mL | |
10 mM | 0.2608 mL | 1.3042 mL | 2.6084 mL | 6.5211 mL | |
20 mM | 0.1304 mL | 0.6521 mL | 1.3042 mL | 3.2606 mL | |
50 mM | 0.0522 mL | 0.2608 mL | 0.5217 mL | 1.3042 mL | |
100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6521 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pantoprazole 102625-70-7 Apoptosis Autophagy Membrane transporter/Ion channel Proton pump release exosome orally Doxorubicin Inhibitor A431 H+/K+-ATPase anti-ulcer BY-1023 anti-secretory stability SKF 96022 inhibit SKF96022 Proton Pump 泮托拉唑 BY1023 BY 1023 MCF-7 PPI SKF-96022 inhibitor