Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Pan-RAS-IN-1是一种广谱的 Ras 抑制剂。Pan-RAS-IN-1破坏 Ras 蛋白及其作用子的相互作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 469 | 现货 | ||
5 mg | ¥ 987 | 现货 | ||
10 mg | ¥ 1,620 | 现货 | ||
25 mg | ¥ 3,250 | 现货 | ||
50 mg | ¥ 4,870 | 现货 | ||
100 mg | ¥ 7,290 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,880 | 现货 |
产品描述 | Pan-RAS-IN-1 is an inhibitor of pan-Ras. It disrupts the interaction of Ras proteins and their effectors. |
体外活性 | Pan-RAS-IN-1 is cytostatic, possibly due to pan-RAS inhibition at some concentrations. Pan-RAS-IN-1 is evaluated in primary T cell acute lymphoblastic leukemia (T-ALL) cells. Selective lethality is observed, with mutant NRAS cells retaining only 20%-40% viability after 5 μM treatment. Pan-RAS-IN-1 binds to KRasG12D-GppNHp with an affinity of less than 20 μM. Pan-RAS-IN-1 binds to Ras proteins and exhibits lethality in cells partially dependent on the expression of Ras proteins. The potency of pan-RAS-IN-1 correlates with the degree of dependency on the mutated isoform over a 5-fold concentration range [1]. |
体内活性 | Pan-RAS-IN-1-treated mice show decreased tumor pERK levels compared with vehicle-treated mice. Pan-RAS-IN-1 administration causes inhibition of tumor growth over 15 days of treatment. A modest increase in cleaved caspase-3 is also observed, showing that pan-RAS-IN-1 has the capacity to induce caspase activation in this model[1]. |
分子量 | 717.65 |
分子式 | C36H41Cl2F3N6O2 |
CAS No. | 1835283-94-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (69.67 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.3934 mL | 6.9672 mL | 13.9344 mL | 34.8359 mL |
5 mM | 0.2787 mL | 1.3934 mL | 2.7869 mL | 6.9672 mL | |
10 mM | 0.1393 mL | 0.6967 mL | 1.3934 mL | 3.4836 mL | |
20 mM | 0.0697 mL | 0.3484 mL | 0.6967 mL | 1.7418 mL | |
50 mM | 0.0279 mL | 0.1393 mL | 0.2787 mL | 0.6967 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Pan-RAS-IN-1 1835283-94-7 GPCR/G Protein MAPK Ras PanRASIN1 inhibit Pan RAS IN 1 Inhibitor inhibitor