首页 GPCR/G Protein 5-HT Receptor Paliperidone
Paliperidone
编号 T0076     别名: 9-hydroxyrisperidone
CAS 144598-75-4     分子式 C23H27FN4O3     分子量 426.48
靶点: 5-HT; Dopamine; H1 receptor; β-adrenergic receptor;
Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.
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规格 库存 单价 数量
50 mg 上海现货 615.00
100 mg 上海现货 1020.00
200 mg 上海现货 1805.00
500 mg 上海现货 3880.00
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生物活性

产品描述

Paliperidone(Invega) is used as an atypical antipsychotic. It applies to the acute and maintenance treatment of schizophrenia. Chemically, paliperidone is the primary active metabolite of the older atypical antipsychotic risperidone.

靶点活性

5-HT,

Dopamine,

H1 receptor,

β-adrenergic receptor,

体外活性

Paliperidone significantly increases the intracellular accumulation of Rh123 and DOX in a concentration-dependent manner. [1] Paliperidone works finely at low concentrations (10 and 50 μM) against Aβ(25-35) and MPP(+) and solely protects SH-SY5Y from hydrogen peroxide. Paliperidone (100 μM) completely diminishes cell reduction induced by different stressors, regardless of their dosages. Paliperidone is demonstrated with higher oxidative stress-scavenging properties than other APDs in several aspects, such as generated bulk glutathione, low HNE, and protein carbonyl productions. [2] Paliperidone enhances dopamine toxicity at the highest dose and is the only AP that significantly increases cell viability (8.1%) compared with cells treated with dopamine alone. [3]

体内活性

化学信息

分子量

426.48

分子式

C23H27FN4O3

CAS

144598-75-4

溶解度

DMSO: 4.3 mg/mL (10 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

store at -80°C

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 2.345 ml 11.724 ml 23.448 ml
5 mM 0.469 ml 2.345 ml 4.69 ml
10 mM 0.234 ml 1.172 ml 2.345 ml
50 mM 0.047 ml 0.234 ml 0.469 ml
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