Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s < 100 μM)[1].
产品描述 | PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC, acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM)[1]. |
靶点活性 | SIRT2:0.25 μM |
体外活性 | PROTAC Sirt2 Degrader-1 (Compound 12; 10 μM, 1-6 hours) induces Sirt2 degradation in HeLa cells[1]. |
分子量 | 852.94 |
分子式 | C40H40N10O8S2 |
CAS No. | 2098487-75-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (117.24 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.1724 mL | 5.8621 mL | 11.7242 mL | 29.3104 mL |
5 mM | 0.2345 mL | 1.1724 mL | 2.3448 mL | 5.8621 mL | |
10 mM | 0.1172 mL | 0.5862 mL | 1.1724 mL | 2.931 mL | |
20 mM | 0.0586 mL | 0.2931 mL | 0.5862 mL | 1.4655 mL | |
50 mM | 0.0234 mL | 0.1172 mL | 0.2345 mL | 0.5862 mL | |
100 mM | 0.0117 mL | 0.0586 mL | 0.1172 mL | 0.2931 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PROTAC Sirt2 Degrader-1 2098487-75-1 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin PROTAC Sirt2 Degrader 1 PROTAC Sirt-2 Degrader-1 PROTAC Sirt2 Degrader1 Inhibitor inhibitor inhibit