Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PQCA 是一种毒蕈碱 M1 受体阳性变构调节剂,具有高度选择性和有效的。PQCA 在恒河猴和人 M1 受体上的 EC50 值分别为 49 nM 和 135 nM,但对其他毒蕈碱受体未表现出活性。PQCA 是减少与阿尔茨海默氏病相关的认知缺陷的潜在化合物。。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,310 | 现货 | ||
5 mg | ¥ 3,230 | 现货 | ||
10 mg | ¥ 4,730 | 现货 | ||
25 mg | ¥ 7,490 | 现货 | ||
50 mg | ¥ 9,870 | 现货 | ||
100 mg | ¥ 13,600 | 现货 | ||
500 mg | ¥ 27,200 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,570 | 现货 |
产品描述 | PQCA is a muscarinic M1 receptor-positive allosteric regulator, which is highly selective and effective. PQCA exhibited EC50 values of 49 nM in rhesus monkey and 135 nM in human M1 receptors, but showed no activity against other muscarinic receptors. PQCA is a potential compound for reducing cognitive deficits associated with Alzheimer's disease. |
靶点活性 | Rhesus M1 receptor:49 nM (EC50), Human M1 receptor:135 nM (EC50), M1 receptor(Human):135 nM (EC50), M1 receptor(Rhesus):49 nM (EC50) |
体内活性 | In male rhesus monkeys, oral administration of PQCA (3-30 mg/kg) effectively mitigates the cognitive impairments induced by scopolamine in both the paired-associates learning (PAL) and the continuous performance task (CPT). Scopolamine-induced blockade of muscarinic signaling results in significant deficits in performance on both tasks. [1] |
分子量 | 388.42 |
分子式 | C22H20N4O3 |
CAS No. | 1144504-35-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9.0 mg/mL (23.2 mM), ultrasonic and warming and heat to 80°C
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5745 mL | 12.8727 mL | 25.7453 mL | 64.3633 mL |
5 mM | 0.5149 mL | 2.5745 mL | 5.1491 mL | 12.8727 mL | |
10 mM | 0.2575 mL | 1.2873 mL | 2.5745 mL | 6.4363 mL | |
20 mM | 0.1287 mL | 0.6436 mL | 1.2873 mL | 3.2182 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PQCA 1144504-35-7 Neuroscience Others AChR Inhibitor inhibitor inhibit