Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PNU-159682 是蒽环类新霉素的代谢产物,是一种 DNA 拓扑异构酶 II 抑制剂,具有出色的细胞毒性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,230 | 现货 | ||
5 mg | ¥ 3,120 | 现货 | ||
10 mg | ¥ 4,990 | 现货 | ||
25 mg | ¥ 7,580 | 现货 | ||
50 mg | ¥ 9,870 | 现货 | ||
100 mg | ¥ 13,800 | 现货 |
产品描述 | PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin. |
靶点活性 | CA IX:25 nM, Topo II unknotting activity:100 μM |
体外活性 | PNU-159682 inhibits a panel of human tumor cell lines (IC70 values in the range of 0.07-0.58 nM). PNU-159682 is 2,360- to 790-fold and 6,420- to 2,100-fold more potent than MMDX and doxorubicin, respectively. PNU-159682 displays cytotoxic effect on CAIX-expressing SKRC-52 cells (IC50: 25 nM). PNU-159682 (10 μM)-DNA adducts contain one or two drug molecules bound to double-stranded DNA. PNU-159682 (100 μM) weakly inhibits topoisomerase II unknotting activity [1][2][3]. |
体内活性 | PNU-159682 (25 nmol/kg) shows an effective antitumor effect in mice bearing SKRC-52 xenografted tumors. PNU-159682 (15 μg/kg, i.v.) displays antitumor activity in mice bearing disseminated murine L1210 leukemia and in MX-1 human mammary carcinoma xenografts at 4 μg/kg[1][3]. |
分子量 | 641.62 |
分子式 | C32H35NO13 |
CAS No. | 202350-68-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 96.7 mg/mL (150.71 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.5586 mL | 7.7928 mL | 15.5855 mL | 38.9639 mL |
5 mM | 0.3117 mL | 1.5586 mL | 3.1171 mL | 7.7928 mL | |
10 mM | 0.1559 mL | 0.7793 mL | 1.5586 mL | 3.8964 mL | |
20 mM | 0.0779 mL | 0.3896 mL | 0.7793 mL | 1.9482 mL | |
50 mM | 0.0312 mL | 0.1559 mL | 0.3117 mL | 0.7793 mL | |
100 mM | 0.0156 mL | 0.0779 mL | 0.1559 mL | 0.3896 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PNU-159682 202350-68-3 DNA Damage/DNA Repair Topoisomerase PNU 159682 inhibit non-Hodgkin’s lymphoma PNU159682 ADCs Toxin acute myeloid leukemia ADC Payload EDV nanocell AML Inhibitor ADC Cytotoxin NMS249 NHL inhibitor