首页 Cytoskeletal Signaling PAK PF-3758309 hydrochloride
PF-3758309 hydrochloride
编号 T4230     别名: PF-03758309 hydrochloride, PF-03758309 hydrochloride
CAS 1279034-84-2     分子式 C25H31ClN8OS     分子量 527.08
靶点: PAK1; PAK3; PAK4; PAK5; PAK6;
PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.
选择批次  
纯度 100.00%
规格 库存 单价 数量
2 mg 上海现货 404.00
5 mg 上海现货 728.00
10 mg 上海现货 1168.00
25 mg 上海现货 1856.00
50 mg 待询 3416.00
100 mg 待询 5368.00
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生物活性

产品描述

PF-3758309, also known as PF-03758309, is a PAK4 inhibitor, is also a n orally bioavailable small-molecule inhibitor of p21-activated kinase 4 (PAK4) with potential antineoplastic activity. PAK4 inhibitor PF-03758309 binds to PAK4, inhibiting PAK4 activity and cancer cell growth. PAK4, a serine/threonine kinase belonging to the p21-activated kinase (PAK) family, is often upregulated in a variety of cancer cell types and plays an important role in cancer cell motility, proliferation, and survival.

靶点活性

PAK1,13.7nM

PAK3,99nM

PAK4,18.7nM

PAK5,18.1nM

PAK6,17.1 nM

体外活性

体内活性

化学信息

分子量

527.08

分子式

C25H31ClN8OS

CAS

1279034-84-2

溶解度

DMSO: 10 mM

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 1.897 ml 9.486 ml 18.972 ml
5 mM 0.379 ml 1.897 ml 3.794 ml
10 mM 0.19 ml 0.949 ml 1.897 ml
50 mM 0.038 ml 0.19 ml 0.379 ml
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