Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PDM2 是一种有效的选择性芳烃受体 (AhR) 拮抗剂,Ki 为 1.2±0.4 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 415 | 现货 | ||
50 mg | ¥ 1,337 | 现货 | ||
100 mg | ¥ 2,323 | 现货 |
产品描述 | PDM 2 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist. |
靶点活性 | AhR:1.2±0.4 nM(Ki) |
体外活性 | In a previous screening study, it was found that the replacement of resveratrol hydroxyls by the same substituent produced compounds with the following order of affinity: OH (resveratrol) , OMe < F < CF3 < Cl (PDM 2). PDM 2 exhibited a Ki of 1.25 for AhR and no affinity for ER, indicating that replacement of hydroxyl with chloride could abolish binding on ER and dramatically increase the affinity for AhR. Moreover, among its analogs PDM 2 was the most potent AhR antagonists in this series, being 10-fold more efficient than resveratrol. PDM 2, devoid of measurable affinity for ER, did not display any effect on ER-driven transcription. Therefore, PDM 2 was considered as a selective AhR modulator with regard to ER. In addition, its trimethoxylated derivatives and 3,5-methoxy derivatives were able to induce cytotoxicity at doses lower than 100 nM, which was consistent with previous data. 3,5-Methoxy derivatives, however, only showed cytotoxicity at concentrations higher than 10 μM [1]. |
分子量 | 283.58 |
分子式 | C14H9Cl3 |
CAS No. | 688348-25-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (176.32 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.5263 mL | 17.6317 mL | 35.2634 mL | 88.1585 mL |
5 mM | 0.7053 mL | 3.5263 mL | 7.0527 mL | 17.6317 mL | |
10 mM | 0.3526 mL | 1.7632 mL | 3.5263 mL | 8.8159 mL | |
20 mM | 0.1763 mL | 0.8816 mL | 1.7632 mL | 4.4079 mL | |
50 mM | 0.0705 mL | 0.3526 mL | 0.7053 mL | 1.7632 mL | |
100 mM | 0.0353 mL | 0.1763 mL | 0.3526 mL | 0.8816 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PDM2 688348-25-6 Immunology/Inflammation Metabolism AhR Aryl Hydrocarbon Receptor inhibit Inhibitor PDM 2 PDM-2 inhibitor