Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2].
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 242 | 现货 | ||
5 mg | ¥ 559 | 现货 | ||
10 mg | ¥ 919 | 现货 | ||
25 mg | ¥ 1,843 | 现货 | ||
50 mg | ¥ 2,952 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 598 | 现货 |
产品描述 | PD151746 is a calpain inhibitor with a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM). Its IC50 values are 0.26 ± 0.03 μM (Ki for μ-calpain) and 5.33 ± 0.77 μM (Ki for m-calpain) [1]. In vitro, PD151746 targets calpain and reduces oxLDL-induced cytotoxicity [2]. |
靶点活性 | m-calpain:5.33 μM, μ calpain:260 nM |
体内活性 | PD151746可使HMEC-1细胞中氧化型低密度脂蛋白诱导的细胞毒性降低。PD151746有效减弱SY5Y细胞中鱼毒素诱导的SLLVY-AMC水解作用。 |
激酶实验 | Akt kinase assay: MM.1S cells are cultured in the presence or absence of perifosine (5 μM, 6 hours) and then stimulated with IL-6 (20 ng/mL, 10 minutes). In vitro akt kinase assay is then carried out using the Akt Kinase Assay Kit. |
分子量 | 237.25 |
分子式 | C11H8FNO2S |
CAS No. | 179461-52-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 44 mg/mL (185.5 mM)
Ethanol: 44 mg/mL (185.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / Ethanol | 1 mM | 4.215 mL | 21.0748 mL | 42.1496 mL | 105.3741 mL |
5 mM | 0.843 mL | 4.215 mL | 8.4299 mL | 21.0748 mL | |
10 mM | 0.4215 mL | 2.1075 mL | 4.215 mL | 10.5374 mL | |
20 mM | 0.2107 mL | 1.0537 mL | 2.1075 mL | 5.2687 mL | |
50 mM | 0.0843 mL | 0.4215 mL | 0.843 mL | 2.1075 mL | |
100 mM | 0.0421 mL | 0.2107 mL | 0.4215 mL | 1.0537 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PD 151746 179461-52-0 Proteases/Proteasome Ubiquitination Cysteine Protease Proteasome PD-151746 PD151746 Inhibitor inhibitor inhibit