Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PAP-1 (5-(4-Phenoxybutoxy)psoralen) 是口服活性的Kv1.3选择性阻滞剂 (EC50=2 nM)。它依赖性阻止 Kv1.3,并优先与通道的 C 型失活状态结合来发挥作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 464 | 现货 | ||
5 mg | ¥ 742 | 现货 | ||
10 mg | ¥ 1,252 | 现货 | ||
25 mg | ¥ 2,767 | 现货 | ||
50 mg | ¥ 3,180 | 现货 | ||
100 mg | ¥ 4,660 | 现货 | ||
200 mg | ¥ 6,640 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 797 | 现货 |
产品描述 | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a selective, and orally active Kv1.3 blocker (EC50: 2 nM). |
靶点活性 | Kv1.5:45 nM (EC50), Kv1.3:2 nM (EC50) |
体外活性 | PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50: 45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels [1, 2]. PAP-1 (2-100 nM; 30 minutes) suppresses the proliferation of CCR7-TEM cells (IC50: 10 nM) [1]. |
体内活性 | PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats [1]. |
细胞实验 | Cell Line: CCR7-TEM cells (anti-CD3 Ab stimulated). Concentration: 2, 10, 25, 100 nM. Incubation Time: 30 minutes [1] |
动物实验 | Animal Model: 9- to 11- week-old female Lewis rats. Dosage: I.P.; three times daily for 48 hours. Administration: 0.3, 1, 3 mg/kg [1] |
别名 | 5-(4-Phenoxybutoxy)psoralen |
分子量 | 350.36 |
分子式 | C21H18O5 |
CAS No. | 870653-45-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 48 mg/mL (137 mM), sonification is recommended.
H2O: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.8542 mL | 14.271 mL | 28.5421 mL | 71.3552 mL |
5 mM | 0.5708 mL | 2.8542 mL | 5.7084 mL | 14.271 mL | |
10 mM | 0.2854 mL | 1.4271 mL | 2.8542 mL | 7.1355 mL | |
20 mM | 0.1427 mL | 0.7136 mL | 1.4271 mL | 3.5678 mL | |
50 mM | 0.0571 mL | 0.2854 mL | 0.5708 mL | 1.4271 mL | |
100 mM | 0.0285 mL | 0.1427 mL | 0.2854 mL | 0.7136 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
PAP-1 870653-45-5 Membrane transporter/Ion channel Potassium Channel KcsA 5-(4-Phenoxybutoxy)psoralen inhibit PAP1 Inhibitor PAP 1 inhibitor