Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxybenzone (Eusolex 4360) 是晒黑和皮肤保护剂中常用的紫外线过滤剂。它是二苯甲酮的衍生物,用作破坏内分泌的化学物质,可穿透胎盘和血脑屏障。它损害自噬,改变表观遗传状态并破坏凋亡神经元细胞中的类维生素 X 受体信号传导。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 289 | 现货 | ||
5 g | ¥ 378 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 235 | 现货 |
产品描述 | Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone. |
体外活性 | A dose-dependent inhibition of PGE2-production is found in the HEPM cell culture following oxybenzone exposure[1]. Benzophenones, including oxybenzone(BP-3) are documented mutagens that increase the rate of damage to DNA, especially when exposed to sunlight. It either can act directly as genotoxicants or become genotoxicants by bioactivation via cytochrome P450 enzymes. Oxybenzone can generate reactive oxygen species, which are potential mutagens, when applied topically to the skin followed by UV light exposure[2]. |
体内活性 | In mice studies, oxybenzone(BP-3) exposure significantly affects fecundity, as well as inducing unexplained mortality in lactating mothers. Studies in both mice and rats demonstrate that generational exposure to oxybenzone(BP-3) reduces body weight, increases liver ([50 %) and kidney weights, induces a 30 % increase in prostate weight, a reduction in immunocompetence, and significantly increases uterine weight in juveniles. In mammals, oxybenzone(BP-3) is renowned for having estrogenic and anti-androgenic activities, causing activation of estrogen receptor proteins and inhibition of androgen receptors[2]. |
细胞实验 | Cells are grown at 37℃ with 100% humidity and 10% CO2. Prior to analyses, cells are subcultured onto 24-well plates and allowed to become 70-90% confluent. On day 1 of the experiment, cells are washed three times with serum-free media containing 0.5% bovine serum albumin (BSA), followed by replacement with the same media that also contained 1 ng/ml of IL-1β with or without oxybenzone. After an exposure time of 24 h, the media are removed, the pH adjusted to 3.5 with HCl, and finally assayed for PGE2-production. (Only for Reference) |
别名 | 二苯酮-3, KAHSCREEN BZ-3, Benzophenone 3, Eusolex 4360, 紫外线吸收剂UV-9, Escalol 567 |
分子量 | 228.24 |
分子式 | C14H12O3 |
CAS No. | 131-57-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 197.2 mM
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 4.3814 mL | 21.9068 mL | 43.8135 mL | 109.5338 mL |
5 mM | 0.8763 mL | 4.3814 mL | 8.7627 mL | 21.9068 mL | |
10 mM | 0.4381 mL | 2.1907 mL | 4.3814 mL | 10.9534 mL | |
20 mM | 0.2191 mL | 1.0953 mL | 2.1907 mL | 5.4767 mL | |
50 mM | 0.0876 mL | 0.4381 mL | 0.8763 mL | 2.1907 mL | |
100 mM | 0.0438 mL | 0.2191 mL | 0.4381 mL | 1.0953 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Oxybenzone 131-57-7 Apoptosis Autophagy Metabolism Retinoid Receptor sun Retinoid X receptors RAR/RXR Inhibitor Retinoic acid receptors 二苯酮-3 KAHSCREEN BZ-3 inhibit filter Benzophenone 3 Eusolex 4360 Benzophenone3 blood-brain placental barriers 紫外线吸收剂UV-9 neuronal Benzophenone-3 Escalol 567 cells inhibitor