Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 5,980 | 8-10周 | ||
50 mg | ¥ 7,770 | 8-10周 | ||
100 mg | ¥ 11,900 | 8-10周 |
产品描述 | Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM). |
靶点活性 | HDAC:15.7 nM |
体外活性 | Oxamflatin is able to significantly inhibit DNA synthesis and cell proliferation. Oxamflatin can induce E-cadherin expression and also reduce cell viability in the MKN-45 cell line. Oxamflatin causes transcriptional activation of junD and morphological reversion in various NIH3T3-derived transformed cell lines. Oxamflatin induces an elongated cell shape with filamentous protrusions as well as the arrest of the cell cycle at the G1 phase in HeLa cells. Oxamflatin displays antiproliferative activity against various mouse and human tumor cell lines with drastic changes in the cell morphology. Oxamflatin greatly increases the transcriptional activity of the CMV promoter in a dose-dependent manner and inhibits intracellular HDAC activity[1][2][3]. |
体内活性 | The ILS of the mice treated with Oxamflatin at the dose of 50 mg/kg is calculated to be more than 67% and one mouse survived over 60 days after tumor inoculation. Injection of Oxamflatin, six times at the dose of 20 mg/kg, shows a significant increase in the days of survival (38% of ILS) [1]. |
别名 | Metacept-3 |
分子量 | 342.37 |
分子式 | C17H14N2O4S |
CAS No. | 151720-43-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (365.10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.9208 mL | 14.6041 mL | 29.2082 mL | 73.0204 mL |
5 mM | 0.5842 mL | 2.9208 mL | 5.8416 mL | 14.6041 mL | |
10 mM | 0.2921 mL | 1.4604 mL | 2.9208 mL | 7.302 mL | |
20 mM | 0.146 mL | 0.7302 mL | 1.4604 mL | 3.651 mL | |
50 mM | 0.0584 mL | 0.2921 mL | 0.5842 mL | 1.4604 mL | |
100 mM | 0.0292 mL | 0.146 mL | 0.2921 mL | 0.7302 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Oxamflatin 151720-43-3 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Metacept-3 Inhibitor inhibitor inhibit