store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Oseltamivir phosphate (GS 4104) 是一种神经氨酸酶抑制剂,可研究流感。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
50 mg | ¥ 196 | 现货 | ||
100 mg | ¥ 316 | 现货 | ||
200 mg | ¥ 497 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 190 | 现货 |
产品描述 | Oseltamivir phosphate (GS 4104) is the phosphate salt of oseltamivir, a synthetic derivative prodrug of ethyl ester with antiviral activity. By blocking neuraminidases on the surfaces of influenza viruses, oseltamivir interferes with host cell release of complete viral particles. |
体外活性 | Oseltamivir Phosphate, anti-Neu1 antibodies, and matrix metalloproteinase-9-specific inhibitor blocks Neu1 activity associated with EGF-stimulated TNBC MDA-MB-231 cells[2]. Oseltamivir slows the spread of influenza (flu) virus between cells in the body by stopping the virus from chemically cutting ties with its host cell. |
体内活性 | Oseltamivir Phosphate monotherapy may be the effective treatment therapy for TNBC(Triple-negative breast cancers)[2]. It is efficacious in treating infections caused by H5N1 and H9N2 influenza viruses in mice[3]. After dosing, the prodrug (Oseltamivir phosphate) is readily absorbed from the gastrointestinal tract and rapidly converted into the active metabolite, OC. In all patient groups, OC has high bioavailability and is systemically distributed to infection sites at concentrations sufficient to inhibit a range of influenza virus neuraminidases[4]. |
细胞实验 | Cells are incubated in 96-well plates (5,000 cells/well) and allowed to adhere for 24 hours in 1× DMEM media containing 10% FCS. The media are replaced with fresh DMEM media containing 5% FCS with or without various concentrations of tamoxifen or OP for indicated time periods. Cell viability is tested using WST-1 cell proliferation assay.(Only for Reference) |
别名 | GS 4104, 磷酸奥司他韦 |
分子量 | 410.4 |
分子式 | C16H28N2O4·H3PO4 |
CAS No. | 204255-11-8 |
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (24.37 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.4366 mL | 12.1832 mL | 24.3665 mL | 60.9162 mL |
5 mM | 0.4873 mL | 2.4366 mL | 4.8733 mL | 12.1832 mL | |
10 mM | 0.2437 mL | 1.2183 mL | 2.4366 mL | 6.0916 mL | |
20 mM | 0.1218 mL | 0.6092 mL | 1.2183 mL | 3.0458 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Oseltamivir phosphate 204255-11-8 Microbiology/Virology Influenza Virus GS4104 Oseltamivir Phosphate inhibit GS 4104 Oseltamivir 磷酸奥司他韦 GS-4104 Inhibitor inhibitor