Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Olmesartan Medoxomil (Benicar) 是血管紧张素 (angiotensin AT1) 受体选择性抑制剂(IC50:66.2 μM)。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 133 | 现货 | ||
5 mg | ¥ 283 | 现货 | ||
10 mg | ¥ 395 | 现货 | ||
50 mg | ¥ 579 | 现货 | ||
100 mg | ¥ 823 | 现货 | ||
200 mg | ¥ 1,380 | 现货 | ||
500 mg | ¥ 2,860 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 493 | 现货 |
产品描述 | Olmesartan Medoxomil (Benicar) is an angiotensin II type 1 receptor blocker that is used to manage hypertension. |
靶点活性 | AT1 receptor:66.2 μM |
体外活性 | Olmesartan Medoxomil significantly reduces liver hydroxyproline content, the mRNA expression of collagen alpha1(I) and alpha-smooth muscle actin (alpha-SMA), and plasma levels of transforming growth factor-beta1 (TGF-beta1). [1] Olmesartan Medoxomil is a pro-drug containing an ester moiety that, after oral administration, is rapidly cleaved to release the active form Olmesartan (RNH-6270). Olmesartan is a highly potent, competitive and selective All AT1 receptor antagonist with almost no antagonistic activity on AT2 and AT4 receptors. [2] |
体内活性 | Olmesartan produces a rapid and long-lasting inhibition of All-induced pressor responses in conscious rats. Oralolmesartan medoxomil also inhibits All-pressor response but onset of the action is slower compared with intravenous administration. Olmesartan Medoxomil exhibits dose-dependent antihypertensive effects in several rat and dog models, with the most marked effects seen in high plasma renin models, when compared with normal or low renin types. Olmesartan medoxomil exhibits, beside antihypertensive effects, beneficial effects in animal models of various types of nephrosis and heart failure, and anti-atherogenic effects in hyperlipidaemic animals. [2] Olmesartan Medoxomil dose-dependently ameliorates the colonic histopathological and biochemical injuries in rats, an effect that is comparable or even better than that of the standard Sulfasalazine. [3] Olmesartan medoxomil significantly reduces the induction of hypoxic cor pulmonale not only on echocardiographical observations but also in brain natriuretic peptide (BNP) in chronic hypoxic rats, TGF-beta and endothelin gene expressions in molecular studies. [4] |
别名 | 奥美沙坦酯, CS 866, Benicar |
分子量 | 558.59 |
分子式 | C29H30N6O6 |
CAS No. | 144689-63-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 82 mg/mL (146.8 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7902 mL | 8.9511 mL | 17.9022 mL | 44.7555 mL |
5 mM | 0.358 mL | 1.7902 mL | 3.5804 mL | 8.9511 mL | |
10 mM | 0.179 mL | 0.8951 mL | 1.7902 mL | 4.4756 mL | |
20 mM | 0.0895 mL | 0.4476 mL | 0.8951 mL | 2.2378 mL | |
50 mM | 0.0358 mL | 0.179 mL | 0.358 mL | 0.8951 mL | |
100 mM | 0.0179 mL | 0.0895 mL | 0.179 mL | 0.4476 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Olmesartan Medoxomil 144689-63-4 Endocrinology/Hormones RAAS Angiotensin Receptor 奥美沙坦酯 CS 866 CS-866 CS866 inhibit Inhibitor Benicar inhibitor