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Octopamine hydrochloride

Octopamine hydrochloride

产品编号 T0469   CAS 770-05-8
别名: 章鱼胺盐酸盐, (±)-p-Octopamine hydrochlorid, (+,-)-Octopamine HCl, 章胺盐酸盐

Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) 是一种与去甲肾上腺素结构相关的生物单胺类物质,在无脊椎动物中起着神经调节剂、神经激素和神经递质的作用。它对转染人 alpha2-肾上腺素受体(ARs)的中国仓鼠卵巢细胞 α2-ARs 有刺激作用。它提高糖原分解、糖酵解、糖异生、摄氧量和门脉灌注压。

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Octopamine hydrochloride Chemical Structure
Octopamine hydrochloride, CAS 770-05-8
规格 价格/CNY 货期 数量
500 mg ¥ 333 现货
1 g ¥ 418 现货
5 g ¥ 585 现货
1 mL * 10 mM (in DMSO) ¥ 418 现货
产品目录号及名称: Octopamine hydrochloride (T0469)
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纯度: 99.89%
纯度: 99.85%
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天然产物信息
生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Octopamine hydrochloride ((±)-p-Octopamine hydrochlorid) is a biogenic monoamine structurally associated with noradrenaline. It can serve as a neurohormone, a neurotransmitter, and a neuromodulator in invertebrates.
体外活性 Octopamine is present in relatively high concentrations in neuronal as well as in non-neuronal tissues of most invertebrate species studied, and modulates almost every physiological process. Octopamine acts as neurohormone including desensitization of sensory inputs, influence on learning and memory, or regulation of the mood of the animal in the central nervous system. Octopamine is the only neuroactive non-peptide transmitter whose physiological role is restricted to invertebrates, and all octopamine receptors belong to the family of G-protein coupled receptors. [1]
体内活性 Octopamine (10 mg/mL) is necessary for the acquisition of sugar memory in Drosophila. [2] Octopamine treatment increases responsiveness to brood pheromone and decreased responsiveness to social inhibition. Octopamine acts as an important source of variation in response thresholds and as a modulator of pheromonal communication in insect societies. [3] Octopamine (10 μM) injected into the mushroom body (MB) calyces or the antennal lobe but not the lateral protocerebral lobe produces a lasting, pairing-specific enhancement of extension of the proboscis. Octopamine (10 μM) injected into the MB calyces results in an additional pairing-specific effect, because it does not lead to an acquisition but a consolidation after conditioning. [4] Octopamine treatment significantly elevates levels of octopamine in the brain and caused a significant dose-dependent increase in the number of new foragers. Octopamine treatment is effective only when given to bees old enough to forage, i.e., older than 4 days of age. Octopamine influences division of labor in honey bee colonies. [5]
别名 章鱼胺盐酸盐, (±)-p-Octopamine hydrochlorid, (+,-)-Octopamine HCl, 章胺盐酸盐
分子量 189.639
分子式 C8H12ClNO2
CAS No. 770-05-8

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMSO: 200.4 mM

H2O: 200.4 mM

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 5.2732 mL 26.3659 mL 52.7318 mL 131.8294 mL
5 mM 1.0546 mL 5.2732 mL 10.5464 mL 26.3659 mL
10 mM 0.5273 mL 2.6366 mL 5.2732 mL 13.1829 mL
20 mM 0.2637 mL 1.3183 mL 2.6366 mL 6.5915 mL
50 mM 0.1055 mL 0.5273 mL 1.0546 mL 2.6366 mL
100 mM 0.0527 mL 0.2637 mL 0.5273 mL 1.3183 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Roeder T, et al. Prog Neurobiol, 1999, 59(5), 533-561. 2. Schwaerzel M, et al. J Neurosci, 2003, 23(33), 10495-10502. 3. Barron AB, et al. J Comp Physiol A Neuroethol Sens Neural Behav Physiol, 2002, 188(8), 603-10. 4. Hammer M, et al. Learn Mem, 1998, 5(1-2), 146-156. 5. Schulz DJ, et al. J Comp Physiol A, 2001, 187(1), 53-61.
Detomidine carboxylic acid Clorprenaline hydrochloride Levobetaxolol hydrochloride (±)-N-Methylcoclaurine Guanabenz Acetate Carazolol Gemfibrozil Tolazoline

相关化合物库

该产品包含在如下化合物库中:
抗癌上市药物库 抗癌药物库 神经退行性疾病化合物库 药物功能重定位化合物库 抗心血管疾病化合物库 人内源代谢化合物库 Plus 抗帕金森病化合物库 人代谢物化合物库 肾上腺素能受体化合物库 FDA上市及药典收录分子库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
%
% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Octopamine hydrochloride 770-05-8 GPCR/G Protein Metabolism Neuroscience Dopamine Receptor Endogenous Metabolite Adrenergic Receptor neurotransmitter Inhibitor p-Octopamine hydrochlorid memory inhibit invertebrates learning 章鱼胺盐酸盐 (±)-p-Octopamine hydrochlorid neurohormone (+,-)-Octopamine HCl Octopamine Hydrochloride neuromodulator 章胺盐酸盐 Octopamine Beta Receptor Octopamine HCl inhibitor

 

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