Powder: -20°C for 3 years | In solvent: -80°C for 1 year
OTSSP167 hydrochloride 是一种高效的,ATP 竞争性的MELK 抑制剂,其 IC50=0.41 nM。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 362 | 现货 | ||
2 mg | ¥ 518 | 现货 | ||
5 mg | ¥ 823 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 1,980 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,450 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 946 | 现货 |
产品描述 | OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM). |
靶点活性 | MELK:0.41 nM (IC50) |
体外活性 | OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer. |
别名 | OTSSP 167 盐酸盐 |
分子量 | 523.88 |
分子式 | C25H29Cl3N4O2 |
CAS No. | 1431698-10-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 33 mg/mL (63 mM), sonification is recommended.
H2O: 7.14 mg/mL (13.63 mM), sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 1.9088 mL | 9.5442 mL | 19.0883 mL | 47.7209 mL |
5 mM | 0.3818 mL | 1.9088 mL | 3.8177 mL | 9.5442 mL | |
10 mM | 0.1909 mL | 0.9544 mL | 1.9088 mL | 4.7721 mL | |
DMSO | 20 mM | 0.0954 mL | 0.4772 mL | 0.9544 mL | 2.386 mL |
50 mM | 0.0382 mL | 0.1909 mL | 0.3818 mL | 0.9544 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
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