Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ON-013100 是有丝分裂的抑制剂,具有抗肿瘤活性。ON-013100能够抑制细胞周期蛋白 D1 的表达。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 698 | 现货 | ||
5 mg | ¥ 1,430 | 现货 | ||
10 mg | ¥ 2,260 | 现货 | ||
25 mg | ¥ 3,830 | 现货 | ||
50 mg | ¥ 5,490 | 现货 | ||
100 mg | ¥ 7,680 | 现货 | ||
500 mg | ¥ 15,300 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 983 | 现货 |
产品描述 | ON-013100 is an antineoplastic drug. ON-013100 also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. |
体外活性 | ON 013100 inhibits the proliferation of MCL (JEKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines at a nanomolar concentration (ON 013100 GI50=6.7-11.2 nM). ON013100 significantly alters the cell cycle profile, dramatically increasing the number of cells in the G2/M phase. Treatment of the cells with even 0.1 μM of ON013100 results in an arrest of the G2/M phase of the cell cycle. ON-013100 induces apoptosis and has activity against most human cancer cell lines in vitro[2][3]. |
分子量 | 394.44 |
分子式 | C19H22O7S |
CAS No. | 865783-95-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (63.38 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.5352 mL | 12.6762 mL | 25.3524 mL | 63.381 mL |
5 mM | 0.507 mL | 2.5352 mL | 5.0705 mL | 12.6762 mL | |
10 mM | 0.2535 mL | 1.2676 mL | 2.5352 mL | 6.3381 mL | |
20 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL | 3.169 mL | |
50 mM | 0.0507 mL | 0.2535 mL | 0.507 mL | 1.2676 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ON-013100 865783-95-5 Cell Cycle/Checkpoint CDK inhibit Inhibitor ON 013100 Cyclin dependent kinase ON013100 inhibitor