Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nrf2-IN-1 是 Nrf2抑制剂,可用于研究急性髓性白血病药物。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,160 | 现货 | ||
5 mg | ¥ 2,890 | 现货 | ||
10 mg | ¥ 3,890 | 现货 | ||
25 mg | ¥ 5,990 | 现货 | ||
50 mg | ¥ 8,230 | 现货 | ||
100 mg | ¥ 11,270 | 现货 | ||
500 mg | ¥ 22,500 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,180 | 现货 |
产品描述 | Nrf2-IN-1 is an nuclear factor-erythroid 2-related factor 2 (Nrf2) inhibitor. Nrf2-IN-1 is developed for the research of acute myeloid leukemia (AML). |
体外活性 |
Nrf2-IN-1 (Compound 4f), that inhibited Nrf2 activity.?4f had a profound growth-inhibitory effect on three AML cell lines, THP-1, HL-60 and U937, and a similar anti-growth effect in a chick embryo model.?Moreover, flow cytometry of AML cells revealed increased apoptosis with 4f (10 μM) treatment for 48 h. The protein levels of cleaved caspase-3 and cleaved poly (ADP-ribose) polymerase were enhanced in all three AML cell types.?Furthermore, Nrf2 protein level was downregulated by 4f.?Upregulation of Nrf2 by tert-butylhydroquinone (tBHQ) or Nrf2 overexpression could ameliorate 4f-induced growth inhibition and apoptosis.?Treatment with 4f reduced both B-cell lymphoma-2 (Bcl-2) expression and Bcl-2/Bcl-2-associated X protein (Bax) ratio, which indicated that 4f induced apoptosis, at least in part, via mitochondrial-dependent signaling.?Therefore, as an Nrf2 inhibitor, the pyrazolyl hydroxamic acid derivative 4f may be a promising agent in AML therapy[1]. |
体内活性 | Nrf2-IN-1 inhibits tumor growth in chicken eggs?via apoptosis?[1]. |
分子量 | 383.87 |
分子式 | C21H22ClN3O2 |
CAS No. | 1610022-76-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (677.31 mM), Sonification is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.605 mL | 13.0252 mL | 26.0505 mL | 65.1262 mL |
5 mM | 0.521 mL | 2.605 mL | 5.2101 mL | 13.0252 mL | |
10 mM | 0.2605 mL | 1.3025 mL | 2.605 mL | 6.5126 mL | |
20 mM | 0.1303 mL | 0.6513 mL | 1.3025 mL | 3.2563 mL | |
50 mM | 0.0521 mL | 0.2605 mL | 0.521 mL | 1.3025 mL | |
100 mM | 0.0261 mL | 0.1303 mL | 0.2605 mL | 0.6513 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nrf2-IN-1 1610022-76-8 Immunology/Inflammation Others Nrf2 inhibit Acute leukemia AML myeloid Inhibitor Nrf2IN1 Keap1-Nrf2 Nrf-2-IN-1 Nrf2 IN 1 inhibitor