keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Notoginsenoside Ft1 是一种植物分离的三七皂苷,具有刺激血管生成的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
2 mg | ¥ 398 | 现货 | ||
5 mg | ¥ 667 | 现货 | ||
10 mg | ¥ 835 | 现货 | ||
25 mg | ¥ 1,319 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 797 | 现货 |
产品描述 | Notoginsenoside Ft1 is a saponin originally isolated from P. notoginseng with diverse biological activities |
体外活性 | Notoginsenoside Ft1 (Ft1) is a novel stimulator of angiogenesis. Ft1 induces proliferation, migration, and tube formation in cultured human umbilical vein endothelial cells (HUVECs). Ft1 increases translocalization of hypoxia-inducible factor-1α (HIF-1α) from cytoplasm to nuclei, where it binds to the vascular endothelial growth factor (VEGF) promoter, increasing the expression of VEGF mRNA and the subsequent secretion of the growth factor. Ft1 induces the activation of PI3K/AKT and Raf/MEK/ERK signaling pathways. Pharmacological inhibition with LY294002, wortmanin or PD98059 reduces Ft1-induced angiogenesis, indicating the important role played by these pathways. In addition, Ft1 induces phosphorylation of the mammalian target of rapamycin (mTOR), and siRNA-mediated mTOR knockdown decreases tube formation, proliferation, transport of HIF-1α into nuclei and VEGF mRNA expression in response to Ft1[1].Among the saponins examined, Notoginsenoside Ft1(Ft1) was the most potent procoagulant and induced dose-dependent platelet aggregation. Ft1 reduced plasma coagulation indexes, decreased tail bleeding time and increased thrombogenesis. Moreover, it potentiated ADP-induced platelet aggregation and increased cytosolic Ca(2+) accumulation, effects that were attenuated by clopidogrel[2]. |
激酶实验 | Platelet aggregation was analysed using a platelet aggregometer. Prothrombin time, activated partial thromboplastin time and thrombin time were measured using a blood coagulation analyser, which was further corroborated with bleeding time and thrombotic assays[2]. |
别名 | 三七皂苷FT1, 三七皂甙 Ft1 |
分子量 | 917.13 |
分子式 | C47H80O17 |
CAS No. | 155683-00-4 |
keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (27.26 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.0904 mL | 5.4518 mL | 10.9036 mL | 27.2589 mL |
5 mM | 0.2181 mL | 1.0904 mL | 2.1807 mL | 5.4518 mL | |
10 mM | 0.109 mL | 0.5452 mL | 1.0904 mL | 2.7259 mL | |
20 mM | 0.0545 mL | 0.2726 mL | 0.5452 mL | 1.3629 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Notoginsenoside Ft1 155683-00-4 Chromatin/Epigenetic Metabolism Others HIF/HIF Prolyl-Hydroxylase inhibit Notoginsenoside Ft 1 Inhibitor 三七皂苷FT1 Notoginsenoside Ft-1 三七皂甙 Ft1 inhibitor