首页 Microbiology/Virology Antibacterial Nitrofurantoin
Nitrofurantoin
编号 T1313     别名: Macrodantin, Furadantine, Furadonine
CAS 67-20-9     分子式 C8H6N4O5     分子量 238.16
靶点: NADPH nitroreductase; Antibacterial;
Nitrofurantoin, an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.
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规格 库存 单价 数量
500 mg 上海现货 395.00
1 g 上海现货 485.00
1 mL * 10 mM (in DMSO) 上海现货 485.00
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生物活性

产品描述

Nitrofurantoin, an antibiotic, inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections.

靶点活性

NADPH nitroreductase,

Antibacterial,

体外活性

体内活性

In vivo, nitrofurantoin (25-100 mg/kg, i.m.) reduces E. coli replication and abscess formation in the renal medulla of infected rats in a dose-dependent manner. It prevents kidney and bladder infection in rats following bladder inoculation with clinical isolates of P. mirabilis. Nitrofurantoin also prevents alkalization of urine as well as calculi and abscess formation in a rat model of P. vulgaris urinary tract infection.

细胞实验

HeLa cells are grown and infected with T. gondii for 24 hr in a 96-well microplate, and then treated with drugs. After 24 hr, 20 μl of MTS solution is added directly into culture wells, followed by incubating for 1.5 hr at 37˚C and measuring the absorbance at 490 nm in a microplate reader. (Only for Reference)

细胞系: HeLa cell

化学信息

分子量

238.16

分子式

C8H6N4O5

CAS

67-20-9

溶解度

Water: Insoluble

Ethanol: 10 mg/mL

DMSO: 40 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

储存条件

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

备注

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.

配制溶液

1 mg 5 mg 10 mg
1 mM 4.199 ml 20.994 ml 41.989 ml
5 mM 0.84 ml 4.199 ml 8.398 ml
10 mM 0.42 ml 2.099 ml 4.199 ml
50 mM 0.084 ml 0.42 ml 0.84 ml
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