Niperotidine
编号 T12228
CAS 84845-75-0
分子式
C20H26N4O5S
分子量
434.51
靶点：
histamine H2 receptor;
Niperotidine is an antagonist of histamine H2-receptor.
生物活性
|
产品描述 |
Niperotidine is an antagonist of histamine H2-receptor. |
|
靶点活性 |
histamine H2 receptor, |
|
体外活性 |
|
|
体内活性 |
Niperotidine is an agent of H2 blocking. After oral administration, it reaches a plasmatic peak within 60-120 min and is eliminates either in the urine or in the faeces, with an enterohepatic circulation[1]. |
化学信息
|
分子量 |
434.51 |
|
分子式 |
C20H26N4O5S |
|
CAS |
84845-75-0 |
|
溶解度 |
（ < 1 mg/ml refers to the product slightly soluble or insoluble ) |
|
储存条件 |
store at -80°C |
|
备注 |
For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months. |
配制溶液
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.301 ml | 11.507 ml | 23.014 ml |
| 5 mM | 0.46 ml | 2.301 ml | 4.603 ml |
| 10 mM | 0.23 ml | 1.151 ml | 2.301 ml |
| 50 mM | 0.046 ml | 0.23 ml | 0.46 ml |
参考文献
- 1. Gasbarrini G, et al. Acute liver injury related to the use of Niperotidine. J Hepatol. 1997 Sep;27(3):583-6.
- 2. Palasciano G, et al. The effect of the H2-antagonist Niperotidine on intragastric acidity in healthy subjects undergoing 24-hour pH-monitoring. Ital J Gastroenterol. 1990 Oct;22(5):291-4.
产品操作手册
