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Nifedipine

Nifedipine

产品编号 T1146   CAS 21829-25-4
别名: BAY-a-1040, Procardia XL, Procardia, 硝苯地平, Adalat

Nifedipine (Procardia) 是一种二氢吡啶类钙通道阻滞剂,可抑制细胞外钙离子跨膜流入心肌和血管平滑肌细胞,导致主要冠状动脉和全身动脉扩张,降低心肌收缩力。它常用于心肌功能不全的相关研究。

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Nifedipine Chemical Structure
Nifedipine, CAS 21829-25-4
规格 价格/CNY 货期 数量
500 mg ¥ 326 现货
1 g ¥ 395 现货
5 g ¥ 578 现货
1 mL * 10 mM (in DMSO) ¥ 395 现货
其他形式的 Nifedipine:
产品目录号及名称: Nifedipine (T1146)
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选择批次  
纯度: 99.39%
纯度: 99.30%
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生物活性
化学信息
存储 & 溶解度
参考文献
产品描述 Nifedipine (Procardia) is a dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents.
体外活性 Nifedipine causes a significant concentration-dependent increase in eNOS protein expression by cultured human coronary artery endothelial cells. [1] Nifedipine antagonizes L-type Ca+ channels found throughout the cardiovascular system, but also blocks Kv channels, which are members of the same supergene family. [2] Nifedipine dose-dependently decreases the values of [(3)H]-thymidine incorporation and total cellular protein content as well as the levels of phosphorylated extracellular signal-regulated protein kinase (ERK) 1/2, mitogen-activated protein kinase kinase (MEK) 1/2, and even the phosphorylation of Pyk2, in vascular smooth muscle cells (VSMC). Nifedipine suppresses the levels of proliferative cell nuclear antigen (PCNA) dose-dependently in both VSMC and balloon-injured thoracic aortae in VSMC. [3]
体内活性 Nifedipine (3 mg/kg) slightly lowers the level of systolic and/or diastolic blood pressure or increased the heart rate in rats. [3] Nifedipine (1 μm) produces a maximal inhibition of the store-operated pathway in choroidal arteriolar smooth muscle. [4] Nifedipine (20 and 40 mg/kg) markedly prevents the HCl plus ethanol-induced gastric mucosal injury and the increase in the content of thiobarbituric acid-reactive substances in the injured mucosa in rats. Nifedipine (20 and 40 mg/kg) dose-dependently promotes the ulcer healing and inhibites the increase in the content of thiobarbituric acid-reactive substances in the ulcerated mucosa in rats. [5]
细胞实验 Cell viability is assessed using an MTT assay. Briefly, a total of 25 μL MTT (1 g/L in PBS) is added to each well before incubation is conducted at 37°C for 4 h. The assay is stopped by the addition of a 100 μL lysis buffer (20% SDS in 50% N'Ndimethylformamide, pH 4.7). Optical density (OD) is measured at the 570 nm wavelength by the use of an ELX-800 microplate assay reader and the results are expressed as a percentage of the absorbance measured in the control cells.
别名 BAY-a-1040, Procardia XL, Procardia, 硝苯地平, Adalat
分子量 346.33
分子式 C17H18N2O6
CAS No. 21829-25-4

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

Ethanol: 12 mg/mL (34.6 mM)

DMSO: 64 mg/mL (184.8 mM)

溶液配制表

可选溶剂 浓度 体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 2.8874 mL 14.4371 mL 28.8742 mL 72.1855 mL
5 mM 0.5775 mL 2.8874 mL 5.7748 mL 14.4371 mL
10 mM 0.2887 mL 1.4437 mL 2.8874 mL 7.2185 mL
20 mM 0.1444 mL 0.7219 mL 1.4437 mL 3.6093 mL
DMSO 50 mM 0.0577 mL 0.2887 mL 0.5775 mL 1.4437 mL
100 mM 0.0289 mL 0.1444 mL 0.2887 mL 0.7219 mL

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器
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输入分子式,点击计算,可计算出产品的分子量。

参考文献

1. Ding Y, et al. J Pharmacol Exp Ther,2000, 292(2), 606-609. 2. Zhang X, et al. J Pharmacol Exp Ther,1997, 281(3), 1247-1256. 3. Hirata A, et al. Br J Pharmacol,2000, 131(8), 1521-1530. 4. Curtis TM, et al. J Physiol,2001, 532(Pt 3), 609-623. 5. Suzuki Y, et al. Jpn J Pharmacol,1998, 78(4), 435-441. 6. Ratre MS, et al. Effect of azithromycin on gingival overgrowth induced by cyclosporine A + nifedipine combination therapy: A morphometric analysis in rats. J Indian Soc Periodontol. 2016 Jul-Aug;20(4):396-401. 7. Liu P, et al. The L-type Ca(2+) Channel Blocker Nifedipine Inhibits Mycelial Growth, Sporulation, and Virulence of Phytophthora capsici. Front Microbiol. 2016 Aug 4;7:1236. 8. Carvajal JA, et al. The Synergic In Vitro Tocolytic Effect of Nifedipine Plus Ritodrine on Human Myometrial Contractility. Reprod Sci. 2017 Apr;24(4):635-640. 9. Yu SS, et al. Nifedipine Increases Iron Content in WKPT-0293 Cl.2 Cells via Up-Regulating Iron Influx Proteins. Front Pharmacol. 2017 Feb 13;8:60

文献引用

1. Wang B, Pei J, Zhang H, et al.Dihydropyridine-derived calcium channel blocker as a promising anti-hantavirus entry inhibitor.Interventions for emerging infectious diseases.2023, 16648714. 2. Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta Pharmacologica Sinica.2023: 1-12.
Talatisamine A2764 dihydrochloride Isopulegol Mitiglinide calcium hydrate SCH-23390 hydrochloride Cromolyn sodium Pimozide BMS-394136

相关化合物库

该产品包含在如下化合物库中:
抗癌药物库 抗癌上市药物库 抗癌临床化合物库 抗癌活性化合物库 FDA 上市药物库 表型筛选靶点鉴定库 药物功能重定位化合物库 神经信号分子库 抗高血压化合物库 自噬库

剂量换算

对于不同动物的给药剂量换算,您也可以参考 更多...

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。

母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。

体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。

第一步:请输入动物实验的基本信息
剂量
mg/kg
每只动物体重
g
给药体积
μL
动物数量
第二步:请输入动物体内配方组成,不同的产品配方组成不同,如有配方需求,可先联系我们提供正确的体内配方。
% DMSO
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% Tween 80
% ddH2O
计算 重置

技术支持

您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。

Keywords

Nifedipine 21829-25-4 Autophagy Membrane transporter/Ion channel Metabolism Neuroscience CaMK Calcium Channel Potassium Channel BAY-a-1040 Ca channels inhibit Procardia XL Inhibitor Ca2+ channels Procardia 硝苯地平 Adalat inhibitor

 

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