Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicaraven 是新型的、化学合成的羟基自由基清除剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
10 mg | ¥ 249 | 现货 | ||
25 mg | ¥ 393 | 现货 | ||
50 mg | ¥ 566 | 现货 | ||
100 mg | ¥ 992 | 现货 | ||
200 mg | ¥ 1,490 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 223 | 现货 |
产品描述 | Nicaraven, a hydroxyl radical scavenger, has neuroprotective and antivasospastic effects. |
体外活性 | Nicaraven causes a dose-dependent, slight inhibition of poly (ADP-ribose) synthetase activation, possibly due to a direct inhibitory effect on the catalytic activity of poly (ADP-ribose) synthetase in RAW murine macrophages stimulated with peroxynitrite. Nicaraven partially protects against the peroxynitrite-induced suppression of mitochondrial respiration in RAW macrophages and causes a slight, dose-dependent inhibition of nitrite production in RAW macrophages stimulated with bacterial lipopolysaccharide. [1] Nicaraven (0.35 mM) significantly inhibits the maximum aggregation rate induced by adenosine diphosphate (ADP) in the healthy volunteer platelets. Nicaraven (1.75 mM) significantly reduces the maximum aggregation rate induced by collagen in platelets. Nicaraven induces dose-dependent inhibition of platelet aggregation in both healthy volunteers and patients with cerebral thrombosis. [2] |
体内活性 | Nicaraven inhibits lipid peroxidation in the liver of beagle dogs, improves hepatic and systemic hemodynamics and energy metabolism, and suppresses liver enzyme release, endothelin-1 elevation in hepatic venous blood, histologic damage, and neutrophil infiltration into the liver. [3] Nicaraven (20 mg/kg) elicits small reductions in infarction volume in male Sprague-Dawley rats subjected to transient focal ischemia. Nicaraven (60 mg/kg) provides significant reductions in the volume of infarction (18.6% and 20.9%) reductions for the pre- and posttreatment groups, respectively, in male Sprague-Dawley rats subjected to transient focal ischemia. [4] |
分子量 | 284.31 |
分子式 | C15H16N4O2 |
CAS No. | 79455-30-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 53 mg/mL (186.4 mM)
H2O: 52 mg/mL (182.9 mM)
DMSO: 53 mg/mL (186.4 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
Ethanol / H2O / DMSO | 1 mM | 3.5173 mL | 17.5864 mL | 35.1729 mL | 87.9322 mL |
5 mM | 0.7035 mL | 3.5173 mL | 7.0346 mL | 17.5864 mL | |
10 mM | 0.3517 mL | 1.7586 mL | 3.5173 mL | 8.7932 mL | |
20 mM | 0.1759 mL | 0.8793 mL | 1.7586 mL | 4.3966 mL | |
50 mM | 0.0703 mL | 0.3517 mL | 0.7035 mL | 1.7586 mL | |
100 mM | 0.0352 mL | 0.1759 mL | 0.3517 mL | 0.8793 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nicaraven 79455-30-4 Others Inhibitor inhibit inhibitor