Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Nicainoprol (RU-42924) 是一种快速钠通道阻断剂,是有效的抗心律失常剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 1,330 | 现货 | ||
5 mg | ¥ 3,370 | 现货 | ||
10 mg | ¥ 4,890 | 现货 | ||
25 mg | ¥ 7,690 | 现货 | ||
50 mg | ¥ 9,870 | 现货 | ||
100 mg | ¥ 13,800 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 3,420 | 现货 |
产品描述 | Nicainoprol (RU-42924) is a fast-sodium-channel blocking drug. Nicainoprol is a potent antiarrhythmic agent. |
体外活性 | The antiarrhythmic agent Nicainoprol is a fast-sodium-channel blocking drug that also protects isolated rat hearts against reperfusion arrhythmias. However, it is without beneficial effects on cardiac hemodynamics and biochemical parameters, in contrast to the ACE inhibitor[1]. |
体内活性 | The effect of the novel antiarrhythmic agent Nicainoprol on coronary occlusion and reperfusion arrhythmia is investigated in isolated working rat hearts and in anesthetized rats. Nicainoprol (10 μM, 5 μM and 100 μM) in isolated working rat hearts induces concentration-related protection against reperfusion arrhythmia without changing the cardiodynamics while the exception of a decrease in heart rate at the highest concentration. Enzyme levels (lactate dehydrogenase and creatine kinase) in the coronary venous effluent, and cardiac tissue concentrations of glycogen, lactate, ATP and creatine phosphate are not affected by Nicainoprol. Given to anesthetized rats, Nicainoprol (5 and 10 mg/kg i.v.) reduces dose dependently in the early post occlusion (0-30 min) period, the percentage of animals with premature ventricular complexes (PVCs) and ventricular tachycardia while completely preventing the occurrence of ventricular fibrillation. In the reperfusion period no animal treated with 5 mg/kg and 12% of the rats treated with 10 mg/kg showed PVCs (the only form of arrhythmia observed in this period) versus 60% of the control rats. Both doses of Nicainoprol induces a decrease in heart rate, blood pressure and myocardial oxygen consumption. The ratio of infarct mass to ventricular mass is significantly reduced by 20% at a dose of 5 mg/kg and by 28% at the dose of 10 mg/kg. Nicainoprol could be useful in the prevention and treatment of arrhythmias associated with acute myocardial infarction[2]. |
别名 | 尼卡普醇, RU-42924 |
分子量 | 369.46 |
分子式 | C21H27N3O3 |
CAS No. | 76252-06-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (148.87 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.7067 mL | 13.5333 mL | 27.0665 mL | 67.6663 mL |
5 mM | 0.5413 mL | 2.7067 mL | 5.4133 mL | 13.5333 mL | |
10 mM | 0.2707 mL | 1.3533 mL | 2.7067 mL | 6.7666 mL | |
20 mM | 0.1353 mL | 0.6767 mL | 1.3533 mL | 3.3833 mL | |
50 mM | 0.0541 mL | 0.2707 mL | 0.5413 mL | 1.3533 mL | |
100 mM | 0.0271 mL | 0.1353 mL | 0.2707 mL | 0.6767 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Nicainoprol 76252-06-7 Membrane transporter/Ion channel Sodium Channel Na+ channels inhibit Inhibitor Na channels 尼卡普醇 RU 42924 RU-42924 RU42924 inhibitor